Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, SP, Brazil.
Mediators Inflamm. 2018 May 8;2018:2456579. doi: 10.1155/2018/2456579. eCollection 2018.
(DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery.
（DM）是一种代谢紊乱疾病，其特征为高血糖和全球范围内的高发病率。高血糖的有害影响包括氧化应激（OS）反应增加和炎症反应增强。DM 损害了肝脏的再生能力，特别是与缺血再灌注（I/R）损伤后的不良预后相关。考虑到对手术后 DM（高血糖）对肝脏影响的知识需求不断增加，本综述旨在介绍最近的出版物，这些出版物涉及 DM（高血糖）对 OS 和炎症过程的影响，这些过程在 I/R 损伤和肝手术后肝脏再生受损中起着至关重要的作用。
