Hall Natalie, Grenier Nicole L, Shah Samir A, Gold Richard, Feller Edward
Alpert Medical School of Brown University, Providence, RI, USA.
Division of Dermatology, Alpert Medical School of Brown University, Providence, RI, USA.
Case Rep Med. 2018 May 8;2018:5726570. doi: 10.1155/2018/5726570. eCollection 2018.
Malignant melanoma is an aggressive tumor with a high potential for distant metastases, including spread to the gallbladder where it represents more than half of all metastases detected at autopsy. Yet, it is rarely symptomatic in life and is a rare cause of acute cholecystitis. Emphysematous cholecystitis is a rare, potentially fatal variant of acute cholecystitis characterized by the presence of gas in the gallbladder lumen or wall. We report a 77-year-old woman with acute emphysematous cholecystitis as the initial feature of recurrent melanoma metastatic to the gallbladder. This exceptional association highlights the need to consider a relapse of malignancy when assessing unexplained abdominal symptoms in any patient with a prior history of melanoma.
恶性黑色素瘤是一种侵袭性肿瘤，具有很高的远处转移潜力，包括转移至胆囊，在尸检中发现的所有转移病例中，转移至胆囊的病例占一半以上。然而，它在临床上很少有症状，是急性胆囊炎的罕见病因。气肿性胆囊炎是一种罕见的、可能致命的急性胆囊炎变体，其特征是胆囊腔或胆囊壁内存在气体。我们报告一名77岁女性，以急性气肿性胆囊炎为复发性黑色素瘤转移至胆囊的首发表现。这种特殊的关联凸显了在评估任何有黑色素瘤病史的患者出现无法解释的腹部症状时，需要考虑恶性肿瘤复发的必要性。
