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白细胞介素-10 在 对激活的小神经胶质细胞的抗炎和抗氧化作用中的关键作用。

The Critical Role of IL-10 in the Antineuroinflammatory and Antioxidative Effects of on Activated Microglia.

机构信息

Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.

OBT Research Center, Faculty of Dental Sciences, Kyushu University, Fukuoka 812-8582, Japan.

出版信息

Oxid Med Cell Longev. 2018 Apr 26;2018:1083596. doi: 10.1155/2018/1083596. eCollection 2018.

DOI:10.1155/2018/1083596
PMID:29854069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5944207/
Abstract

Maxim. ex Balf. (), a traditional Tibetan medicine, is known to exert various bioactivities, including anti-inflammatory and antioxidative activities. The present study was conducted to investigate anti-inflammatory and antioxidative effects of on activated microglia. (10 g/ml) significantly inhibited the mean protein level of interleukin-1 (IL-1) in the organotypic hippocampal slice cultures following treatment with chromogranin A (CGA, 10 nM) and pancreastatin (10 nM), endogenous microglial activators present in senile plaques. also significantly inhibited the expression and production of inflammatory and oxidative molecules, including IL-1, tumor necrosis factor-, and nitric oxide, by cultured microglia after treatment with CGA. These effects of are considered to be mediated by the secretion of interleukin-10 (IL-10) from microglia, because neutralizing antibodies against IL-10 significantly canceled these effects. To explore the causative components of responsible for inducing the secretion of IL-10, the effects of seven components of on the IL-10 expression in microglia were examined. Among them, aloe-emodin (10 M) and (+)-catechin (30 M) were able to induce the secretion of IL-10 from cultured microglia. Therefore, aloe-emodin and (+)-catechin are deemed responsible for the antineuroinflammatory and antioxidative effects of through the secretion of IL-10 from microglia. Accordingly, is considered potentially useful for the treatment of AD.

摘要

蒙药（），作为一种传统的藏药，已被证实具有多种生物活性，包括抗炎和抗氧化活性。本研究旨在探究对激活小胶质细胞的抗炎和抗氧化作用。（10g/ml）可显著抑制脑片培养物中嗜铬粒蛋白 A（CGA，10nM）和胰增血糖素原（pancreastatin，10nM）作用后的白细胞介素-1（IL-1）平均蛋白水平，CGA 和 pancreastatin 是老年斑中存在的内源性小胶质细胞激活剂。（）还可显著抑制经 CGA 处理后的培养小胶质细胞中炎症和氧化分子（包括 IL-1、肿瘤坏死因子-α和一氧化氮）的表达和产生。这些作用被认为是通过小胶质细胞分泌白细胞介素-10（IL-10）介导的，因为 IL-10 的中和抗体显著取消了这些作用。为了探究（）中诱导 IL-10 分泌的活性成分，我们研究了（）的七种成分对小胶质细胞中 IL-10 表达的影响。其中，芦荟大黄素（10μM）和（+）-儿茶素（30μM）能够诱导培养的小胶质细胞分泌 IL-10。因此，芦荟大黄素和（+）-儿茶素被认为通过小胶质细胞分泌 IL-10 而具有抗神经炎症和抗氧化作用。因此，（）被认为对 AD 的治疗具有潜在的应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfc1/5944207/4def9cc85fa9/OMCL2018-1083596.010.jpg
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