School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China.
Biomed Res Int. 2018 May 8;2018:8174345. doi: 10.1155/2018/8174345. eCollection 2018.
Ginseng is a traditional Chinese medicine with a wide range of pharmacological activities. Ginsenosides are the major constituents of ginseng. Ginsenosides have the unique biological activity and medicinal value, such as antitumor, anti-inflammatory, antioxidation, and inhibition of cell apoptosis. With the increase of stress in life, the incidence of nervous system diseases is also increasing. Neurological diseases pose a huge burden on people's life and health. In recent years, some studies have shown that ginsenosides have a certain role in the prevention and treatment of neurological diseases. However, the research is still in its infancy, and the relevant mechanisms are complex. In the paper, we review the effects and mechanisms of ginsenosides on epilepsy, depression, cerebral ischemia reperfusion injury, Alzheimer's disease, and Parkinson's disease. We hope to provide a theoretical basis for the treatment of nervous system diseases by ginsenosides.
人参是一种具有广泛药理活性的传统中药。人参皂苷是人参的主要成分。人参皂苷具有独特的生物活性和药用价值,如抗肿瘤、抗炎、抗氧化和抑制细胞凋亡。随着生活压力的增加,神经系统疾病的发病率也在增加。神经系统疾病给人们的生活和健康带来了巨大的负担。近年来,一些研究表明,人参皂苷在预防和治疗神经系统疾病方面具有一定的作用。然而,研究仍处于起步阶段,相关机制复杂。本文综述了人参皂苷对癫痫、抑郁、脑缺血再灌注损伤、阿尔茨海默病和帕金森病的作用及其机制。我们希望为人参皂苷治疗神经系统疾病提供理论依据。