SEC Nanotechnology, Far Eastern Federal University, Vladivostok 690950, Russia.
Center of Bioanalytical Investigation and Molecular Design, I.M. Sechenov First Moscow State Medical University, Moscow 119048, Russia.
Mol Med Rep. 2019 Apr;19(4):2975-2998. doi: 10.3892/mmr.2019.9972. Epub 2019 Feb 19.
Ginseng is one of the main representatives of traditional Chinese medicine and presents a wide range of pharmacological actions. Ginsenosides are the main class of active compounds found in ginseng. They demonstrate unique biological activity and medicinal value, namely anti-tumour, anti‑inflammatory and antioxidant properties, as well as anti-apoptotic properties. Increasing levels of stress in life are responsible for the increased incidence of nervous system diseases. Neurological diseases create a huge burden on the lives and health of individuals. In recent years, studies have indicated that ginsenosides play a pronounced positive role in the prevention and treatment of neurological diseases. Nevertheless, research is still at an early stage of development, and the complex mechanisms of action involved remain largely unknown. This review aimed to shed light into what is currently known about the mechanisms of action of ginsenosides in relation to Alzheimer's disease. Scientific material and theoretical bases for the treatment of nervous system diseases with purified Panax ginseng extracts are also discussed.
人参是中药的主要代表之一，具有广泛的药理作用。人参皂苷是人参中主要的活性化合物。它们具有独特的生物活性和药用价值，如抗肿瘤、抗炎和抗氧化特性，以及抗细胞凋亡特性。生活中压力的增加是导致神经系统疾病发病率上升的原因。神经系统疾病给个人的生活和健康带来了巨大的负担。近年来的研究表明，人参皂苷在预防和治疗神经系统疾病方面发挥着显著的积极作用。然而，研究仍处于早期阶段，其涉及的复杂作用机制在很大程度上尚不清楚。本综述旨在探讨人参皂苷在阿尔茨海默病方面的作用机制，同时讨论以纯化的人参提取物治疗神经系统疾病的科学依据和理论基础。
