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儿童期精神病性体验与整个青春期和成年早期的全球功能较差有关。

Childhood psychotic experiences are associated with poorer global functioning throughout adolescence and into early adulthood.

机构信息

Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Department of Psychology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

出版信息

Acta Psychiatr Scand. 2018 Jul;138(1):26-34. doi: 10.1111/acps.12907. Epub 2018 May 31.

DOI:10.1111/acps.12907
PMID:29855047
Abstract

BACKGROUND

Psychotic experiences (PEs) are common in childhood and have been associated with concurrent mental disorder and poorer global functioning. Little is known about the effects of childhood PEs on future functioning. We investigated the effects of childhood PEs on global functioning from childhood into early adulthood.

METHOD

Fifty-six participants from a community sample completed all three waves of the Adolescent Brain Development study (T1x¯ Age: 11.69, T2x¯ Age: 15.80 T3x¯Age: 18.80). At each phase, participants completed a clinical interview assessing for PEs, mental disorder and global function. Repeated measures models, adjusted for mental disorder and gender, were used to compare current (C-GAF) and most severe past (MSP-GAF) functioning in participants who had reported PEs in childhood and controls.

RESULTS

Participants with a history of PEs had significantly poorer C-GAF (P < 0.001) and MSP-GAF scores (P < 0.001). Poorer functioning was evident in childhood (C-GAF: P = 0.001; MSP-GAF: P < 0.001), adolescence (C-GAF: P < 0.001; MSP-GAF: P = 0.004) and early adulthood (C-GAF: P = 0.001; MSP-GAF: P = 0.076).

DISCUSSION

Children who report PEs have persistently poorer functioning through to early adulthood. The longitudinal association between childhood PEs and global functioning highlights the underlying global vulnerability in children reporting PEs, beyond what can be explained by mental disorder.

摘要

背景

精神病性体验(PEs)在儿童期很常见,与同时存在的精神障碍和较差的整体功能有关。关于儿童期 PEs 对未来功能的影响知之甚少。我们调查了儿童期 PEs 对儿童期到成年早期整体功能的影响。

方法

来自社区样本的 56 名参与者完成了青少年大脑发育研究(T1x¯年龄:11.69,T2x¯年龄:15.80 T3x¯年龄:18.80)的所有三个阶段。在每个阶段,参与者都完成了一次临床访谈,评估 PEs、精神障碍和整体功能。使用调整了精神障碍和性别的重复测量模型,比较了在儿童期报告过 PEs 的参与者和对照组中当前(C-GAF)和最严重过去(MSP-GAF)的功能。

结果

有 PEs 病史的参与者的 C-GAF(P<0.001)和 MSP-GAF 评分明显较差(P<0.001)。在儿童期(C-GAF:P=0.001;MSP-GAF:P<0.001)、青春期(C-GAF:P<0.001;MSP-GAF:P=0.004)和成年早期(C-GAF:P=0.001;MSP-GAF:P=0.076),功能障碍都很明显。

讨论

报告 PEs 的儿童在整个成年早期都存在持续较差的功能。儿童期 PEs 与整体功能之间的纵向关联突出了报告 PEs 的儿童的潜在整体脆弱性,这超出了可以用精神障碍来解释的范围。

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