Byun Jung Ick, Shin Yu Yong, Chung Sung Eun, Shin Won Chul
Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
J Clin Neurol. 2018 Jul;14(3):291-295. doi: 10.3988/jcn.2018.14.3.291. Epub 2018 Apr 27.
This study aimed to determine the subjective and objective improvements in sleep quality after treatment with gamma-aminobutyric acid (GABA; 300 mg daily) extracted from unpolished rice germ.
This study was a prospective, randomized, double-blind, and placebo-controlled trial. In total, 40 patients who complained of insomnia symptoms were enrolled and randomly assigned to the GABA treatment group (n=30) or the placebo group (n=10). Polysomnography was performed, and sleep questionnaires were administered before treatment and after 4 weeks of treatment.
After 4 weeks of treatment the sleep latency had decreased [13.4±15.7 min at pretreatment vs. 5.7±6.2 min at posttreatment (mean±SD), p=0.001] and the sleep efficacy had increased (79.4±12.9% vs. 86.1±10.5%, p=0.018) only in the GABA treatment group. Adverse events occurred in four subjects (10%).
This study shows that treatment with unpolished-rice-germ-derived GABA improved not only the subjective sleep quality but also the objective sleep efficacy without severe adverse events.
本研究旨在确定用糙胚芽提取的γ-氨基丁酸（GABA；每日300毫克）治疗后睡眠质量的主观和客观改善情况。
本研究为前瞻性、随机、双盲、安慰剂对照试验。总共招募了40名主诉失眠症状的患者，并随机分配到GABA治疗组（n = 30）或安慰剂组（n = 10）。在治疗前和治疗4周后进行多导睡眠图检查，并发放睡眠问卷。
仅在GABA治疗组中，治疗4周后睡眠潜伏期缩短[治疗前为13.4±15.7分钟，治疗后为5.7±6.2分钟（均值±标准差），p = 0.001]，睡眠效率提高（79.4±12.9%对86.1±10.5%，p = 0.018）。4名受试者（10%）出现不良事件。
本研究表明，用糙胚芽衍生的GABA治疗不仅改善了主观睡眠质量，还提高了客观睡眠效率，且无严重不良事件。
