Kim Dong Hwan, Jun Jin Sun, Kim Ryul
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.
J Clin Neurol. 2018 Jul;14(3):345-350. doi: 10.3988/jcn.2018.14.3.345. Epub 2018 May 31.
The optic nerve sheath diameter (ONSD) is an indirect marker of the intracranial pressure, but the normal range of ONSD as measured using magnetic resonance imaging (MRI) and its associations with clinical parameters and the eyeball transverse diameter (ETD) remain unclear.
We included 314 healthy adults who underwent brain MRI examinations for health screening between June 2014 and September 2017. The ONSD and ETD of each eye were calculated using time-of-flight magnetic resonance angiography. Linear regression analyses were performed to assess the relationships between ONSD and variables including age, sex, height, weight, body mass index (BMI), mean arterial blood pressure (MABP), intraocular pressure (IOP), and ETD. We further investigated a normative value for the ONSD/ETD ratio and its associated factors.
The mean ONSD and ETD were 4.71 mm [95% confidence interval (CI), 4.66-4.75 mm] and 21.24 mm (95% CI, 21.13-21.35 mm), respectively. Multiple linear regression analysis showed that ONSD was only associated with ETD (p<0.001), with it being independent of age, sex, height, weight, BMI, MABP, and IOP. The ONSD/ETD ratio had a mean value of 0.22 (95% CI, 0.22-0.22), and was not correlated with age, sex, height, weight, BMI, MABP, or IOP.
This study determined the normative value of MRI-based ONSD in healthy Korean adults. There was a strong correlation between the ETD and ONSD, which can be presented as the ONSD/ETD ratio. This parameter needs to be investigated further in disease populations.
视神经鞘直径（ONSD）是颅内压的一个间接指标，但使用磁共振成像（MRI）测量的ONSD正常范围及其与临床参数和眼球横径（ETD）的关联仍不清楚。
我们纳入了2014年6月至2017年9月期间因健康筛查而接受脑部MRI检查的314名健康成年人。使用时间飞跃磁共振血管造影术计算每只眼睛的ONSD和ETD。进行线性回归分析以评估ONSD与包括年龄、性别、身高、体重、体重指数（BMI）、平均动脉血压（MABP）、眼压（IOP）和ETD等变量之间的关系。我们进一步研究了ONSD/ETD比值的正常参考值及其相关因素。
平均ONSD和ETD分别为4.71mm [95%置信区间（CI），4.66 - 4.75mm]和21.24mm（95%CI，21.13 - 21.35mm）。多元线性回归分析表明，ONSD仅与ETD相关（p<0.001），且独立于年龄、性别、身高、体重、BMI、MABP和IOP。ONSD/ETD比值的平均值为0.22（95%CI，0.22 - 0.22），且与年龄、性别、身高、体重、BMI、MABP或IOP均无相关性。
本研究确定了韩国健康成年人基于MRI的ONSD正常参考值。ETD与ONSD之间存在很强的相关性，可表示为ONSD/ETD比值。该参数在疾病人群中需要进一步研究。
