基于适体的多功能配体修饰上转换纳米粒子用于靶向 PDT 和生物成像。
Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging.
机构信息
Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Nanoscale. 2018 Jun 14;10(23):10986-10990. doi: 10.1039/c8nr01096j.
Abstract
We designed an aptamer-based multifunctional ligand which, upon conjugation to the surface of upconversion nanoparticles (UCNPs), could realize phase transfer, covalent photosensitizer (PS) loading, and cancer cell targeting in one simple step. The as-built PDT nanodrug is selectively internalized into cancer cells and it exhibits highly efficient and selective cytotoxicity.
摘要
我们设计了一种基于适体的多功能配体，将其与上转换纳米粒子（UCNPs）表面缀合后，可在一步反应中实现相转移、共价光敏剂（PS）负载和癌细胞靶向。构建的 PDT 纳米药物可选择性地被内吞进入癌细胞，并表现出高效和选择性的细胞毒性。
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