Li Tuanwei, Yan Lifeng
CAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China.
Pharmaceuticals (Basel). 2018 Nov 30;11(4):133. doi: 10.3390/ph11040133.
Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.
光动力疗法（PDT）因其微创性和非全身毒性，在一些实体肿瘤及其他疾病的治疗中是一种有吸引力的治疗方式。然而，光敏剂的疏水性和非选择性、肿瘤组织固有的严重缺氧以及光的穿透深度有限，限制了光动力疗法在临床上的进一步应用。功能性聚合物纳米颗粒可用作精确光动力疗法的纳米载体。在此，我们阐明光动力疗法在癌症治疗中的机制和应用，然后综述一些调节光敏剂生物分布和激活的策略，以改善或利用肿瘤缺氧微环境来增强光动力治疗效果。
