Department of Biochemistry, Panjab University, Chandigarh, India.
J Biochem Mol Toxicol. 2012 Oct;26(10):393-8. doi: 10.1002/jbt.21433. Epub 2012 Jul 16.
Carbofuran, an anticholinestrase carbamate, is commonly used as an insecticide. Its toxic effect on kidney is less established. The present study was designed to investigate the effect of carbofuran on kidneys and to understand the mechanism involved in its nephrotoxicity. Male Wistar rats were divided into two groups of eight animals each; control animals received sunflower oil (vehicle) and carbofuran exposed animals were treated with carbofuran (1 mg/kg body weight) orally for 28 days. At the end of the treatment, significant increase was observed in urea and creatinine levels in serum along with the inhibition of acetylcholinesterase, suggesting nephrotoxicity. The antioxidant defense system of animals treated with carbofuran was altered in terms of increased lipid peroxidation, reduced glutathione, and total thiols and decreased activity of antioxidant enzymes (superoxide dismutase and catalase). The results indicate that carbofuran is nephrotoxic and increased oxidative stress appears to be involved in its nephrotoxic effects.
呋喃丹，一种氨基甲酸酯类抗胆堿酯酶杀虫剂，通常被用作杀虫剂。其对肾脏的毒性作用尚未得到充分证实。本研究旨在探讨呋喃丹对肾脏的影响，并了解其肾毒性的作用机制。雄性 Wistar 大鼠分为两组，每组 8 只；对照组动物给予葵花籽油（载体），呋喃丹暴露组动物经口给予呋喃丹（1mg/kg 体重）连续 28 天。治疗结束时，血清中尿素和肌酐水平显著升高，同时乙酰胆堿酯酶受到抑制，提示存在肾毒性。用呋喃丹处理的动物的抗氧化防御系统发生改变，表现为脂质过氧化增加、还原型谷胱甘肽和总巯基减少以及抗氧化酶（超氧化物歧化酶和过氧化氢酶）活性降低。结果表明，呋喃丹具有肾毒性，氧化应激的增加似乎与其肾毒性作用有关。
