Zhang Qian, Chen Kaddie Kwok, Liu Wei-Feng, Huang Guo-Fu
Department of Ophthalmology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China.
Department of Ophthalmology, the Third Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China.
Int J Ophthalmol. 2018 May 18;11(5):844-847. doi: 10.18240/ijo.2018.05.21. eCollection 2018.
To evaluate the influence of age and axial length (AL) on the position of the fovea in patients with high myopia (HM).
In this prospective study, 96 patients (186 eyes) with HM were consecutively recruited from the Third Affiliated Hospital of Nanchang University. DRI-OCT Atlantis, fundus imaging, and IOL Master were used in this study. Three indices were measured: the distance between the fovea and the optic nerve head (ONH) center (DFO), the vertical distance between the fovea and the horizontal line pass of the ONH center (VDFO), and the horizontal distance between the fovea and the vertical line pass of the ONH center (HDFO). These measurements were used to analyze the effects of different age groups (A1, A2, A3 groups) and AL (AL1, AL2, AL3, AL4 groups) on these indices.
The results showed that there was no statistical significance in DFO among the age and AL groups (=0.46, 0.37; =0.62, 0.76, respectively). In HDFO, there was also no statistical significance among the age and AL groups (=0.10, 0.48; =0.90, 0.69, respectively). In VDFO, however, the difference in the age and AL groups was statistically significant (=3.21, 3.12; =0.04, 0.02, respectively). Thus, VDFO were correlated with age and AL (=0.21, 0.23, all <0.01), while HDFO and DFO were not correlated with age and AL (=0.30, >0.05).
In high myopia, the foveal position changes mainly in the vertical direction along with factors of age and AL.
评估年龄和眼轴长度（AL）对高度近视（HM）患者黄斑中心凹位置的影响。
在这项前瞻性研究中，连续纳入了南昌大学第三附属医院的96例（186只眼）HM患者。本研究使用了DRI-OCT Atlantis、眼底成像和IOL Master。测量了三个指标：黄斑中心凹与视神经乳头（ONH）中心之间的距离（DFO）、黄斑中心凹与ONH中心水平连线之间的垂直距离（VDFO）以及黄斑中心凹与ONH中心垂直连线之间的水平距离（HDFO）。这些测量用于分析不同年龄组（A1、A2、A3组）和AL（AL1、AL2、AL3、AL4组）对这些指标的影响。
结果显示，年龄组和AL组之间DFO无统计学意义（分别为=0.46，0.37；=0.62，0.76）。在HDFO方面，年龄组和AL组之间也无统计学意义（分别为=0.10，0.48；=0.90，0.69）。然而，在VDFO方面，年龄组和AL组之间的差异具有统计学意义（分别为=3.21，3.12；=0.04，0.02）。因此，VDFO与年龄和AL相关（=0.21，0.23，均<0.01），而HDFO和DFO与年龄和AL不相关（=0.30，>0.05）。
在高度近视中，黄斑中心凹位置主要沿垂直方向随年龄和AL因素而变化。
