Tang Wen-Quan, Luo Yu-Lin, Wang Xi-Lang, Duan Xuan-Chu
Department of Ophthalmology, Hunan Children's Hospital, Changsha 410007, Hunan Province, China.
Changsha Aier Eye Hospital, Changsha 410011, Hunan Province, China.
Int J Ophthalmol. 2023 Jan 18;16(1):102-107. doi: 10.18240/ijo.2023.01.15. eCollection 2023.
To analyze the correlation of age, spherical equivalent (SE), and axial length (AL) with the microcirculation of optic nerve head (ONH) in high myopia (HM).
In this cross-sectional clinical study, 164 right eyes were included. Optical coherence tomography angiography (OCTA) was used to detect ONH vessel density. Eyes were classified based on age, SE, and AL. Groups of Age1, Age2, and Age3 were denoted for age classification (Age1<20y, 20y≤Age2<30y, Age3≥30y); Groups SE1, SE2, and SE3 for the SE classification (-9≤SE1<-6 D, -12≤SE2<-9 D, SE3<-12 D); Groups AL1, AL2, AL3, and AL4 for the AL classification (AL1<26 mm, 26≤AL2<27 mm, 27≤AL3<28 mm, AL4≥28 mm).
No significant difference was observed in vessel density among the Age1, Age2, and Age3 groups (all >0.05) and the SE1, SE2, and SE3 groups (all >0.05). No significant difference was observed in the intrapapillary vascular density (IVD) among AL1, AL2, AL3, and AL4 groups (>0.05). However, a significant decrease was found in the peripapillary vascular density (PVD) in the AL1, AL2, AL3, and AL4 groups (=3.605, =0.015), especially in the inferotemporal (IT; =6.25, <0.001), temporoinferior (TI; =2.865, =0.038), and temporosuperior (TS; =6.812, <0.001) sectors. The IVD was correlated with age (=-0.190, <0.05) but not with SE or AL (>0.05). The PVD was correlated with AL (=-0.236, <0.01) but not with age or SE (>0.05).
With the increase of AL, the IVD remains stable while the PVD decreases, especially in the three directions of temporal (IT, TI, and TS). The main cause of microcirculation reduction may be related to AL elongation rather than an increase in age or SE.
分析高度近视（HM）患者年龄、等效球镜度（SE）和眼轴长度（AL）与视神经乳头（ONH）微循环的相关性。
在这项横断面临床研究中，纳入了164只右眼。采用光学相干断层扫描血管造影（OCTA）检测ONH血管密度。根据年龄、SE和AL对眼睛进行分类。年龄分类分为Age1、Age2和Age3组（Age1<20岁，20岁≤Age2<30岁，Age3≥30岁）；SE分类分为SE1、SE2和SE3组（-9≤SE1<-6 D，-12≤SE2<-9 D，SE3<-12 D）；AL分类分为AL1、AL2、AL3和AL4组（AL1<26 mm，26≤AL2<27 mm，27≤AL3<28 mm，AL4≥28 mm）。
Age1、Age2和Age3组之间以及SE1、SE2和SE3组之间的血管密度均无显著差异（均>0.05）。AL1、AL2、AL3和AL4组之间的视乳头内血管密度（IVD）无显著差异（>0.05）。然而，AL1、AL2、AL3和AL4组的视乳头周围血管密度（PVD）显著降低（F=3.605，P=0.015），尤其是在颞下（IT；F=6.25，P<0.001）、颞下象限（TI；F=2.865，P=0.038）和颞上（TS；F=6.812，P<0.001）象限。IVD与年龄相关（r=-0.190，P<0.05），但与SE或AL无关（均>0.05）。PVD与AL相关（r=-0.236，P<0.01），但与年龄或SE无关（均>0.05）。
随着AL的增加，IVD保持稳定，而PVD降低，尤其是在颞侧的三个方向（IT、TI和TS）。微循环减少的主要原因可能与AL延长有关，而非年龄或SE增加。
