[人类群体中DNA多态性的检测策略]

[Strategies for the detection of DNA polymorphism in human populations].

作者信息

Bastié-Sigeac F, Mornet E, Lucotte G

出版信息

Rev Fr Transfus Immunohematol. 1985 Feb;28(1):27-44. doi: 10.1016/s0338-4535(85)80088-x.

DOI:10.1016/s0338-4535(85)80088-x

Abstract

We develop here several models concerning strategies for detection of restriction polymorphisms in humans. These different strategies concern the numbers of individuals to test in a DNA collection, the nature of restriction enzyme to utilize, and the length of the probes. For enzyme utilization different strategies are based on (i) the nature of the restriction site; (ii) the mean length of restriction fragments obtained; (iii) the methylated cytosine characteristics in the CG doublets. Each of these approaches are tested in experimental situations.

摘要

我们在此开发了几种关于人类限制性多态性检测策略的模型。这些不同的策略涉及在DNA样本中进行检测的个体数量、所用限制酶的性质以及探针的长度。对于酶的使用，不同的策略基于：（i）限制位点的性质；（ii）获得的限制片段的平均长度；（iii）CG双联体中甲基化胞嘧啶的特征。每种方法都在实验情况下进行了测试。

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[Strategies for the detection of DNA polymorphism in human populations].[人类群体中DNA多态性的检测策略]

Rev Fr Transfus Immunohematol. 1985 Feb;28(1):27-44. doi: 10.1016/s0338-4535(85)80088-x.

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