一种限制片段长度分布模型。
A model for restriction fragment length distributions.
作者信息
Bishop D T, Williamson J A, Skolnick M H
出版信息
Am J Hum Genet. 1983 Sep;35(5):795-815.
Abstract
We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms.
摘要
我们在此基于人类DNA二聚体频率开发了一种限制片段长度分布模型。计算了已知限制酶的平均片段长度。使用一系列用一组限制酶筛选的任意单拷贝DNA探针杂交的数据对该模型进行了测试。结果显示该模型拟合良好。我们将该模型应用于一组酶扫描多少DNA的问题。然后将此结果进一步应用于优化插入/缺失DNA多态性的搜索。
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