Altunbaş Rıza, Eren Mehmet Ali, Altıparmak İbrahim Halil, Karaaslan Hüseyin, Sabuncu Tevfik
Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey.
Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.
Exp Clin Endocrinol Diabetes. 2019 Jan;127(1):37-40. doi: 10.1055/a-0664-7746. Epub 2018 Aug 14.
Although hyperthyroidism may be associated with atherosclerosis, its pathogenesis is not well known. TSH receptor antibody (TRAb) has been shown to be responsible for increased orbital fat tissue in Graves ophthalmopathy. Epicardial fat tissue thickness (EFT) has been found to be increased in case of overt hyperthyroidism. In our study, we aimed to investigate if TRAb is associated with the increased EFT in newly diagnosed hyperthyroidism.
Twenty six TRAb positive (group 1) and 26 TRAb negative (group 2) newly diagnosed patients with hyperthyroidism, and 26 healthy control subjects (group 3) were enrolled. EFT was measured by the same cardiologist using an echocardiography device. Serum TRAb levels were measured by the radio-receptor assay and levels above 1.75 IU/L were considered as positive.
There was no difference among groups in terms of age, gender and body mass index. Although there was no significant difference between group 1 and 2, both group 1 (0.38±0.15 cm) and group 2 (0.4±0.17 cm) had significantly higher EFT levels when compared to group 3 (0.25±0.06 cm) (p=0.004 and p=0.001, respectively). However we did not find any correlation between TRAb and EFT levels.
The results of our study suggested that EFT was increased in hyperthyroidism and this increasing was not dependent of TRAb level. EFT elevation might be depending directly to the cardiovascular effects of hyperthyroidism.
尽管甲状腺功能亢进可能与动脉粥样硬化有关，但其发病机制尚不清楚。促甲状腺激素受体抗体（TRAb）已被证明是格雷夫斯眼病眶脂肪组织增加的原因。在显性甲状腺功能亢进患者中，已发现心外膜脂肪组织厚度（EFT）增加。在我们的研究中，我们旨在调查TRAb是否与新诊断的甲状腺功能亢进患者EFT增加有关。
纳入26例新诊断的TRAb阳性（第1组）和26例TRAb阴性（第2组）甲状腺功能亢进患者，以及26例健康对照者（第3组）。由同一位心脏病专家使用超声心动图设备测量EFT。通过放射受体测定法测量血清TRAb水平，高于1.75IU/L的水平被视为阳性。
三组在年龄、性别和体重指数方面无差异。虽然第1组和第2组之间没有显著差异，但与第3组（0.25±0.06cm）相比，第1组（0.38±0.15cm）和第2组（0.4±0.17cm）的EFT水平均显著更高（分别为p=0.004和p=0.001）。然而，我们未发现TRAb与EFT水平之间存在任何相关性。
我们的研究结果表明，甲状腺功能亢进时EFT增加，且这种增加不依赖于TRAb水平。EFT升高可能直接取决于甲状腺功能亢进对心血管的影响。
