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肯尼亚国家营养支持方案对结核病诊断后失访的影响。

Impact of a national nutritional support programme on loss to follow-up after tuberculosis diagnosis in Kenya.

机构信息

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

World Health Organization, Nairobi, Kenya.

出版信息

Int J Tuberc Lung Dis. 2018 Jun 1;22(6):649-654. doi: 10.5588/ijtld.17.0537.

Abstract

SETTING

Undernourishment is prevalent among tuberculosis (TB) patients. Nutritional support is given to TB patients to prevent and treat undernourishment; it is also used to improve treatment outcomes and as an incentive to keep patients on treatment.

OBJECTIVE

To determine whether nutritional support is associated with a reduction in the risk of loss to follow-up (LTFU) among TB patients in Kenya.

DESIGN

This was a retrospective cohort study using national programmatic data. Records of 362 685 drug-susceptible TB patients from 2012 to 2015 were obtained from Treatment Information from Basic Unit (TIBU), a national case-based electronic data recording system. Patients who were LTFU were compared with those who completed treatment.

RESULTS

Nutrition counselling was associated with an 8% reduction in the risk of LTFU (RR 0.92, 95%CI 0.89-0.95), vitamins were associated with a 7% reduction (adjusted RR [aRR] 0.93, 95%CI 0.90-0.96) and food support was associated with a 10% reduction (aRR 0.90, 95%CI 0.87-0.94). Among patients who received food support, the addition of nutrition counselling was associated with a 23% reduction in the risk of LTFU (aRR 0.77, 95%CI 0.67-0.88).

CONCLUSION

Nutritional support was associated with a reduction in the risk of LTFU. Providing nutrition counselling is important for patients receiving food support.

摘要

背景

营养不良在结核病(TB)患者中很普遍。为预防和治疗营养不良,为 TB 患者提供营养支持;它也用于改善治疗结果,并作为激励患者继续治疗的手段。

目的

确定在肯尼亚,营养支持是否与降低结核病患者失访(LTFU)风险相关。

设计

这是一项使用国家规划数据的回顾性队列研究。从国家基于病例的电子数据记录系统治疗信息基础单位(TIBU)获得了 2012 年至 2015 年 362685 例药物敏感结核病患者的记录。将失访患者与完成治疗的患者进行比较。

结果

营养咨询与 LTFU 风险降低 8%相关(RR 0.92,95%CI 0.89-0.95),维生素与 LTFU 风险降低 7%相关(调整后的 RR [aRR] 0.93,95%CI 0.90-0.96),而食物支持与 LTFU 风险降低 10%相关(aRR 0.90,95%CI 0.87-0.94)。在接受食物支持的患者中,添加营养咨询与 LTFU 风险降低 23%相关(aRR 0.77,95%CI 0.67-0.88)。

结论

营养支持与降低 LTFU 风险相关。为接受食物支持的患者提供营养咨询很重要。

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