a Department of Physical Medicine and Rehabilitation , University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital , Bursa , Turkey.
b Department of Pulmonology , University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital , Bursa , Turkey.
Aging Male. 2019 Jun;22(2):109-115. doi: 10.1080/13685538.2018.1477935. Epub 2018 Jun 4.
This study aims to investigate the effect of smoking on sexual functions in AS patients.
A total of 67 male AS patients with a median age of 34 years (range: 18-57) reporting sexual activity at least for the past 4 weeks period were included. Patients were divided into smokers (Group 1, n = 47) and non-smokers (Group 2, n = 20). Fagerström test for nicotine dependence, smoking history, exhaled carbon monoxide test were recorded for smoking AS patients. Visual analogue scale (VAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life (ASQoL), International Index of Erectile Function (IIEF), Beck Depression Inventory (BDI) were filled for both groups.
There was no significant difference between smokers and non-smokers in all evaluation parameters. BASMI scores were significantly lower in the mild dependency subgroup as compared to those with moderate or severe dependency (p = .005 and p = .007, respectively). Total IIEF score and IIEF categories correlated significantly with BASDAI, BASFI, BASMI, ASQoL, pain, fatigue, and cumulative smoking. BDI showed an inverse correlation with the IIEF score and IIEF category (p < .001 r = -0.520, p < .001 r = -0.508, respectively).
Sexual function in AS patients is associated with the pain, fatigue, disease activity, functional status, quality of life, depression as well as the cumulative exposure to smoking, and that sexual functions tend to decline with increasing degree of cigarette dependency.
本研究旨在探讨吸烟对 AS 患者性功能的影响。
共纳入 67 例中位年龄为 34 岁（范围：18-57 岁）的男性 AS 患者，这些患者至少在过去 4 周内有过性行为。患者分为吸烟者（第 1 组，n=47）和非吸烟者（第 2 组，n=20）。记录吸烟 AS 患者的尼古丁依赖程度的 Fagerström 测试、吸烟史、呼气一氧化碳测试。两组患者均填写视觉模拟量表（VAS）、Bath 强直性脊柱炎疾病活动指数（BASDAI）、Bath 强直性脊柱炎测量指数（BASMI）、Bath 强直性脊柱炎功能指数（BASFI）、强直性脊柱炎生活质量指数（ASQoL）、国际勃起功能指数（IIEF）、贝克抑郁量表（BDI）。
在所有评估参数中，吸烟者和非吸烟者之间没有显著差异。与中度或重度依赖组相比，轻度依赖亚组的 BASMI 评分显著降低（p=0.005 和 p=0.007）。总 IIEF 评分和 IIEF 类别与 BASDAI、BASFI、BASMI、ASQoL、疼痛、疲劳和累积吸烟量显著相关。BDI 与 IIEF 评分和 IIEF 类别呈负相关（p<0.001 r=-0.520，p<0.001 r=-0.508）。
AS 患者的性功能与疼痛、疲劳、疾病活动度、功能状态、生活质量、抑郁以及吸烟的累积暴露有关，且性功能随着吸烟依赖程度的增加而下降。
