Department of Physical Medicine and Rehabilitation, Dicle University, Diyarbakir, Turkey.
Rheumatol Int. 2013 Mar;33(3):623-9. doi: 10.1007/s00296-012-2432-2. Epub 2012 Apr 7.
The aim of this study was to explore the impact of ankylosing spondylitis (AS) and the disease-related variables on the patients' sexual function according to the International Index of Erectile Function (IIEF) scoring system. A total of 70 sexually active male AS patients and 60 healthy controls were enrolled in this study. Their demographic data were evaluated, and the pain was assessed according to the visual analogue scale (VAS). Laboratory tests were conducted in order to measure the C-reactive protein (CRP) and erythrocyte sedimentation rates (ESR) of the patients. The disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional statement was evaluated with the help of the Bath Ankylosing Spondylitis Functional Index (BASFI) and with the scores obtained from the spinal measurements with the Bath Ankylosing Spondylitis Metrology Index (BASMI). The Bath Ankylosing Spondylitis Radiology Index (BASRI) was used to evaluate the radiological damage. The disease-related quality of life was measured with the Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL). The anxiety and depression level of the patients was revealed through the Hospital Anxiety and Depression Scale (HADS). In comparison with the healthy control group, patients with AS had significantly lower scores in each of the 5 domains of the IIEF (p < 0.0001). The BASDAI, BASFI, BASMI, BASRI, ASQoL, HADS scores and CRP levels were negatively correlated with IIEF (p < 0.05). Orgasmic function and sexual desire scores were significantly lower in patients with peripheral arthritis (p < 0.05). No significant correlation was observed with the disease duration, smoking status, pain (VAS), and ESR levels when the total scores and the scores from the domains of IIEF were compared. The multivariate regression analyses indicated that BASFI and BASMI were independently associated with the sexual function. The sexual function is impaired in male patients with AS. This impairment in the sexual function is especially correlated with the BASFI and BASMI among the clinical and laboratory parameters.
本研究旨在根据国际勃起功能指数(IIEF)评分系统探讨强直性脊柱炎(AS)及其疾病相关变量对患者性功能的影响。本研究共纳入 70 例有性功能的男性 AS 患者和 60 例健康对照者。评估他们的人口统计学数据，并根据视觉模拟评分(VAS)评估疼痛。进行实验室检查以测量患者的 C 反应蛋白(CRP)和红细胞沉降率(ESR)。使用 Bath 强直性脊柱炎疾病活动指数(BASDAI)评估疾病活动度。使用 Bath 强直性脊柱炎功能指数(BASFI)和 Bath 强直性脊柱炎计量学指数(BASMI)的脊柱测量结果评估功能状态。使用 Bath 强直性脊柱炎放射学指数(BASRI)评估放射学损伤。使用强直性脊柱炎生活质量问卷(ASQoL)测量疾病相关的生活质量。通过医院焦虑抑郁量表(HADS)揭示患者的焦虑和抑郁水平。与健康对照组相比，AS 患者的 IIEF 五个领域的评分均显著降低(p<0.0001)。BASDAI、BASFI、BASMI、BASRI、ASQoL、HADS 评分和 CRP 水平与 IIEF 呈负相关(p<0.05)。外周关节炎患者的性高潮功能和性欲评分显著降低(p<0.05)。当比较 IIEF 的总分和各领域的评分时，与疾病持续时间、吸烟状况、疼痛(VAS)和 ESR 水平均无显著相关性。多变量回归分析表明，BASFI 和 BASMI 与性功能独立相关。男性 AS 患者的性功能受损。这种性功能障碍与 BASFI 和 BASMI 等临床和实验室参数密切相关。
