戒烟对强直性脊柱炎吸烟患者的疾病活动度、功能丧失和生活质量有何影响？
How Does Smoking Cessation Affect Disease Activity, Function Loss, and Quality of Life in Smokers With Ankylosing Spondylitis?
机构信息
From the Departments of Pulmonary Diseases.
Physical Medicine and Rehabilitation, Health Sciences University Bursa Yüksek İhtisas Education & Research Hospital, Bursa, Turkey.
出版信息
J Clin Rheumatol. 2019 Oct;25(7):288-296. doi: 10.1097/RHU.0000000000000851.
BACKGROUND
Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease that can progressively restrict spinal mobility.
OBJECTIVE
This study aimed to investigate how smoking cessation by AS patients affects disease activity and their psychological state, physical mobility, lung function, and quality of life.
MATERIALS AND METHODS
This was a longitudinal, single-blind, controlled, and observational study on 92 AS patients. Pulmonary function test, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, chest expansion, Short-Form 36, and Ankylosing Spondylitis Quality of Life were evaluated. The patients were divided into smokers (group 1 = 54) and nonsmokers (group 2 = 38). The smokers were divided further into subgroups of those who quit smoking (group 1a = 17) and those who did not (group 1b = 37). Groups 1a and 1b patients were compared in terms of their baseline data and data 6 months after smoking cessation. In addition, group 1a patients' baseline data and data 6 months after smoking cessation were compared statistically.
RESULTS
There was no statistically significant difference between groups 1a and 1b after 6 months in terms of the evaluated parameters, except for BASDAI. Bath Ankylosing Spondylitis Disease Activity Index was significantly lower in group 1a than group 1b (p = 0.02), indicating that. When the baseline data and data after 6 months of group 1a were compared, a significant improvement was found in BASDAI (p = 0.001), Bath Ankylosing Spondylitis Functional Index (p = 0.001), chest expansion (p = 0.001), ankylosing spondylitis quality of life (p = 0.003), and subparameters physical function (p = 0.015), physical role strength (p = 0.05), power/live/vitality (p = 0.025), social functioning (p = 0.039), pain (p = 0.036), and general health perception (p = 0.05) of Short-Form 36, as well as forced expiratory volume in the first second (p = 0.003) and forced vital capacity (p = 0.007).
CONCLUSIONS
We observed significant improvements in disease activity, physical mobility, and quality of life in AS patients who quit smoking.
背景
强直性脊柱炎（AS）是一种慢性系统性炎症性疾病，可逐渐限制脊柱的活动度。
目的
本研究旨在探讨 AS 患者戒烟如何影响疾病活动度以及他们的心理状态、身体活动度、肺功能和生活质量。
材料和方法
这是一项针对 92 例 AS 患者的纵向、单盲、对照、观察性研究。评估了肺功能测试、Bath 强直性脊柱炎疾病活动指数（BASDAI）、Bath 强直性脊柱炎功能指数、Bath 强直性脊柱炎度量指数、胸廓扩张度、SF-36 问卷和强直性脊柱炎生活质量。患者分为吸烟者（第 1 组 = 54 例）和非吸烟者（第 2 组 = 38 例）。吸烟者进一步分为戒烟组（第 1a 组 = 17 例）和未戒烟组（第 1b 组 = 37 例）。比较了第 1a 组和第 1b 组的基线数据和戒烟 6 个月后的随访数据。此外，还对第 1a 组患者的基线数据和戒烟 6 个月后的随访数据进行了统计学比较。
结果
戒烟 6 个月后，第 1a 组和第 1b 组在评估的参数方面无统计学差异，除 BASDAI 外。第 1a 组的 BASDAI 明显低于第 1b 组（p = 0.02），表明。比较第 1a 组的基线数据和戒烟 6 个月后的随访数据时，发现 BASDAI（p = 0.001）、Bath 强直性脊柱炎功能指数（p = 0.001）、胸廓扩张度（p = 0.001）、强直性脊柱炎生活质量（p = 0.003）和生理功能（p = 0.015）、生理角色力量（p = 0.05）、力量/活力/生命力（p = 0.025）、社会功能（p = 0.039）、疼痛（p = 0.036）和一般健康感知（p = 0.05）有显著改善，以及用力呼气量（p = 0.003）和用力肺活量（p = 0.007）。
结论
我们观察到戒烟的 AS 患者疾病活动度、身体活动度和生活质量有显著改善。
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