肠系膜明串珠菌NTM048菌株的佐剂活性胞外多糖对树突状细胞的免疫刺激作用。
Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048.
作者信息
Matsuzaki Chiaki, Takagaki Chikahiro, Higashimura Yasuki, Nakashima Yukari, Hosomi Koji, Kunisawa Jun, Yamamoto Kenji, Hisa Keiko
机构信息
a Research Institute for Bioresources and Biotechnology , Ishikawa Prefectural University, Suematsu , Nonoichi , Japan.
b Laboratory of Vaccine Materials and Laboratory of Gut Environmental System , National Institutes of Biomedical Innovation, Health and Nutrition , Osaka , Japan.
出版信息
Biosci Biotechnol Biochem. 2018 Sep;82(9):1647-1651. doi: 10.1080/09168451.2018.1482195. Epub 2018 Jun 4.
This study evaluated the immunostimulative effect on bone marrow-derived dendritic cells (DCs) of adjuvant-active exopolysaccharide (EPS) produced by Leuconostoc mesenteroides strain NTM048. EPS stimulation increased IL-6, IL-10, IL-12, and retinal dehydrogenase (RALDH) gene expression levels and induced retinoic acid-synthesizing RALDH-active DCs, which play a crucially important role in controlling adaptive immune responses in mucosa.
本研究评估了肠系膜明串珠菌NTM048菌株产生的具有佐剂活性的胞外多糖（EPS）对骨髓来源的树突状细胞（DCs）的免疫刺激作用。EPS刺激增加了白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、白细胞介素-12（IL-12）和视黄醛脱氢酶（RALDH）基因的表达水平，并诱导了合成视黄酸的RALDH活性DCs，其在控制黏膜适应性免疫反应中起着至关重要的作用。
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