Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan.
Department of Food Science, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa 921-8836, Japan.
Biosci Microbiota Food Health. 2016;35(1):51-5. doi: 10.12938/bmfh.2015-020. Epub 2015 Oct 6.
The effects of Leuconostoc mesenteroides strain NTM048 and type strain JCM6124(T) on the murine immune system were characterized. Although the bacterial cells and exopolysaccharides of each strain induced immunoglobulin A production in Peyer's patch cells, the effects of NTM048 were more potent than those of JCM6124(T). Oral administration of the cells of each strain increased the fecal immunoglobulin A content in NTM048-treated mice, but not in JCM6124(T)-treated mice. A flow cytometric analysis showed that the CD4(+) T-cell populations in the mouse spleens tended to increase in the NTM048 group. These results suggest that immunomodulating ability is characteristic of strain NTM048.
研究了肠膜明串珠菌 NTM048 菌株和模式菌株 JCM6124(T) 对小鼠免疫系统的影响。尽管每种菌株的细菌细胞和胞外多糖都能诱导派氏结细胞产生免疫球蛋白 A，但 NTM048 的作用比 JCM6124(T)更强。口服给予每种菌株的细胞均能增加 NTM048 处理小鼠的粪便免疫球蛋白 A 含量，但对 JCM6124(T)处理的小鼠没有影响。流式细胞分析表明，NTM048 组小鼠脾脏中的 CD4(+)T 细胞群有增加的趋势。这些结果表明，免疫调节能力是 NTM048 菌株的特征。
