Graduate School of Pharmaceutical Sciences, Kyoto University.
Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University.
Chem Pharm Bull (Tokyo). 2022;70(2):155-161. doi: 10.1248/cpb.c21-00919.
Exopolysaccharides (EPSs) occur widely in natural products made by bacteria, fungi and algae. Some EPSs have intriguing biological properties such as anticancer and immunomodulatory activities. Our group has recently found that EPSs generated from Leuconostoc mesenteroides ssp. mesenteroides strain NTM048 (NTM048 EPS) enhanced a production of mucosal immunoglobulin A (IgA) of mouse. Herein, we described the synthesis and evaluation of the tetrasaccharide fragments of NTM048 EPS to obtain information about the molecular mechanism responsible for the IgA-inducing activity.
胞外多糖 (EPSs) 广泛存在于细菌、真菌和藻类产生的天然产物中。一些 EPSs 具有有趣的生物学特性，如抗癌和免疫调节活性。我们的研究小组最近发现，来源于肠膜明串珠菌亚种肠膜明串珠菌菌株 NTM048 (NTM048 EPS) 的 EPS 增强了小鼠粘膜免疫球蛋白 A (IgA) 的产生。在此，我们描述了 NTM048 EPS 的四糖片段的合成和评价，以获得负责 IgA 诱导活性的分子机制的信息。
