Technical R&D, GSK Vaccines, 53100 Siena, Italy.
Preclinical R&D, GSK Vaccines, 53100 Siena, Italy.
Molecules. 2018 Jun 2;23(6):1340. doi: 10.3390/molecules23061340.
The incidence of infectious diseases caused by several bacterial pathogens such as type b, , and , has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. The structures of the bacterial capsular polysaccharide (CPS) antigens, extracted and purified from microbial cultures and obtained with very high purity, show that many of them are decorated by O-acetyl groups. While these groups are often considered important for the structural identity of the polysaccharides, they play a major role in the functional immune response to some vaccines such as meningococcal serogroup A and Vi, but do not seem to be important for many others, such as meningococcal serogroups C, W, Y, and type III Group B . This review discusses the O-acetylation status of CPSs and its role in the immunological responses of these antigens.
在过去的 25 年中，通过使用糖缀合物疫苗，乙型、丙型和戊型等几种细菌病原体引起的传染病的发病率显著降低。从微生物培养物中提取和纯化的细菌荚膜多糖 (CPS) 抗原的结构表明，其中许多抗原都被 O-乙酰基修饰。虽然这些基团通常被认为是多糖结构同一性的重要因素，但它们在某些疫苗（如脑膜炎球菌 A 组和 6 型、9 型多糖结合疫苗）的功能性免疫反应中起着重要作用，但对于许多其他疫苗（如脑膜炎球菌 C 组、W 组、Y 组和 3 型 B 组）似乎并不重要。本文综述了 CPS 的 O-乙酰化状态及其在这些抗原免疫反应中的作用。
