爱泼斯坦-巴尔病毒DNA聚合酶与几种抗病毒核苷类似物5'-三磷酸的相互作用。
Interaction of Epstein-Barr virus DNA polymerase and 5'-triphosphates of several antiviral nucleoside analogs.
作者信息
Chiou J F, Cheng Y C
出版信息
Antimicrob Agents Chemother. 1985 Mar;27(3):416-8. doi: 10.1128/AAC.27.3.416.
Abstract
The 5'-triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methylcytosine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-(1,3-dihydroxy-2-propoxymethyl)guanine had lower Ki values for Epstein-Barr virus DNA polymerase than has been reported elsewhere for host DNA polymerase. Inhibition of DNA elongation by these analogs ranged from moderate to strong, suggesting that preferential incorporation of these analogs into DNA by virus DNA polymerase may contribute to antiviral selectivity.
摘要
1-（2'-脱氧-2'-氟-β-D-阿拉伯呋喃糖基）-5-甲基尿嘧啶、1-（2'-脱氧-2'-氟-β-D-阿拉伯呋喃糖基）-5-碘胞嘧啶、1-（2'-脱氧-2'-氟-β-D-阿拉伯呋喃糖基）-5-甲基胞嘧啶、9- [（2-羟乙氧基）甲基]鸟嘌呤和9-（1,3-二羟基-2-丙氧基甲基）鸟嘌呤的5'-三磷酸酯对爱泼斯坦-巴尔病毒DNA聚合酶的Ki值低于其他地方报道的宿主DNA聚合酶的Ki值。这些类似物对DNA延伸的抑制作用从中度到强烈不等，这表明病毒DNA聚合酶优先将这些类似物掺入DNA中可能有助于抗病毒选择性。
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