Regalado Ibarra Adriana Margarita, Legendre Loïc, Munday John S
1 West Coast Veterinary Dental Services, Vancouver, British Columbia, Canada.
2 Veterinary Pathology, Institute of Veterinary, Animal & Biomedical Sciences, Massey University, New Zealand.
J Vet Dent. 2018 Jun;35(2):79-95. doi: 10.1177/0898756418774575.
This case report describes a rare case of a persistent canine papillomavirus type 1 (CPV-1)-induced oral papilloma that underwent malignant transformation into an oral squamous cell carcinoma (OSCC) in a 3-year-old Labrador retriever cross. Initially, the patient had multiple and multifocal verrucous lesions populating the oral cavity exclusively. The papillomas persisted despite multiple surgical ablations, azithromycin, interferon α-2b, alternative medicines, and off-label drug use of an immunostimulant. After 1 year and 6 months, an aggressive lesion developed at the level of the left mandibular first molar (309) and progressed to a well-differentiated invasive OSCC. The presence of CPV-1 DNA in the OSCC, and the known oncogenic abilities of CPV-1, suggests that this virus might have played a significant role in the emergence of the OSCC that ultimately led to the patient's euthanasia due to poor quality of life. This is the first well-documented case where OSCC has developed from an oral papilloma caused by CPV-1 in which the presence of coinfection by another papillomavirus was excluded by multiple polymerase chain reaction tests using various primers.
本病例报告描述了一例罕见的持续性犬1型乳头瘤病毒（CPV-1）诱导的口腔乳头瘤病例，该病例在一只3岁的拉布拉多混血犬中发生恶性转化，发展为口腔鳞状细胞癌（OSCC）。最初，该患者仅在口腔内出现多个多灶性疣状病变。尽管进行了多次手术切除、使用阿奇霉素、干扰素α-2b、替代药物以及超说明书使用免疫刺激剂，但乳头瘤仍持续存在。1年零6个月后，左侧下颌第一磨牙（309）水平出现侵袭性病变，并进展为高分化浸润性OSCC。OSCC中CPV-1 DNA的存在以及CPV-1已知的致癌能力表明，该病毒可能在OSCC的发生中起了重要作用，最终由于生活质量差导致患者实施安乐死。这是第一例有充分记录的由CPV-1引起的口腔乳头瘤发展为OSCC的病例，其中通过使用各种引物的多重聚合酶链反应试验排除了另一种乳头瘤病毒共感染的存在。
