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H+-gradient-dependent active transport of tetraethylammonium cation in apical-membrane vesicles isolated from kidney epithelial cell line LLC-PK1.从肾上皮细胞系LLC-PK1分离的顶端膜囊泡中H⁺梯度依赖性四乙铵阳离子的主动转运。
Biochem J. 1985 Apr 1;227(1):199-203. doi: 10.1042/bj2270199.
2
Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles.大鼠肾刷状缘和基底外侧膜囊泡中四乙铵的载体介导转运系统
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Decreased cellular toxicity of neomycin in a clonal cell line isolated from LLC-PK1.从LLC-PK1分离的克隆细胞系中，新霉素的细胞毒性降低。
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本文引用的文献

1
Sugar transport in the LLC-PK1 renal epithelial cell line: similarity to mammalian kidney and the influence of cell density.LLC-PK1肾上皮细胞系中的糖转运：与哺乳动物肾脏的相似性及细胞密度的影响
J Cell Physiol. 1980 Sep;104(3):375-89. doi: 10.1002/jcp.1041040311.
2
Transepithelial transport in cell culture: D-glucose transport by a pig kidney cell line (LLC-PK1).细胞培养中的跨上皮运输：猪肾细胞系（LLC-PK1）对D-葡萄糖的运输
J Membr Biol. 1981 Mar 15;59(1):13-8. doi: 10.1007/BF01870816.
3
Na+-dependent sugar transport in a cultured epithelial cell line from pig kidney.猪肾培养上皮细胞系中的钠依赖性糖转运
J Membr Biol. 1980;54(1):31-8. doi: 10.1007/BF01875374.
4
Na+-dependent hexose transport in vesicles from cultured renal epithelial cell line.来自培养的肾上皮细胞系的囊泡中的钠依赖性己糖转运
Am J Physiol. 1982 Nov;243(5):C293-8. doi: 10.1152/ajpcell.1982.243.5.C293.
5
Characterization of neutral amino acid uptake by cultured epithelial cells from pig kidney.猪肾培养上皮细胞对中性氨基酸摄取的特性研究
J Cell Physiol. 1982 Aug;112(2):182-8. doi: 10.1002/jcp.1041120205.
6
Expression of a differentiated transport function in apical membrane vesicles isolated from an established kidney epithelial cell line. Sodium electrochemical potential-mediated active sugar transport.从一个已建立的肾上皮细胞系分离的顶端膜囊泡中分化转运功能的表达。钠电化学势介导的活性糖转运。
J Biol Chem. 1982 Aug 10;257(15):8680-86.
7
Polarized amino acid transport by an epithelial cell line of renal origin (LLC-PK1). The basolateral systems.肾源性上皮细胞系（LLC-PK1）介导的极化氨基酸转运。基底外侧转运系统。
J Biol Chem. 1982 Jun 25;257(12):6802-8.
8
The use of isolated membrane vesicles to study epithelial transport processes.使用分离的膜囊泡来研究上皮运输过程。
J Membr Biol. 1980 Jul 15;55(2):81-95. doi: 10.1007/BF01871151.
9
Phosphate uptake by a kidney cell line (LLC-PK1).肾细胞系（LLC-PK1）对磷酸盐的摄取。
Am J Physiol. 1983 Jul;245(1):F22-31. doi: 10.1152/ajprenal.1983.245.1.F22.
10
Polarized amino acid transport by an epithelial cell line of renal origin (LLC-PK1). The apical systems.肾源性上皮细胞系（LLC-PK1）的极化氨基酸转运。顶端转运系统。
J Biol Chem. 1983 Feb 25;258(4):2543-7.

从肾上皮细胞系LLC-PK1分离的顶端膜囊泡中H⁺梯度依赖性四乙铵阳离子的主动转运。

H+-gradient-dependent active transport of tetraethylammonium cation in apical-membrane vesicles isolated from kidney epithelial cell line LLC-PK1.

作者信息

Inui K, Saito H, Hori R

出版信息

Biochem J. 1985 Apr 1;227(1):199-203. doi: 10.1042/bj2270199.

DOI:10.1042/bj2270199
PMID:2986603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144826/
Abstract

Transport of [3H]tetraethylammonium (NEt4+), an organic cation, has been studied by using apical-membrane vesicles isolated from cultured kidney epithelial cell line LLC-PK1. The uptake of NEt4+ by apical-membrane vesicles was osmotically sensitive, time-dependent and saturable. The presence of an H+ gradient ([H+]i greater than [H+]o) induced a marked stimulation of NEt4+ uptake against its concentration gradient (overshoot phenomenon), and this concentrative uptake was inhibited by HgCl2. These results suggest that apical membranes isolated from the LLC-PK1 cells retain the transport characteristics of NEt4+ similar to those observed in renal brush-border membranes.

摘要

利用从培养的肾上皮细胞系LLC-PK1分离的顶端膜囊泡，对有机阳离子[3H]四乙铵（NEt4+）的转运进行了研究。顶端膜囊泡对NEt4+的摄取对渗透压敏感、具有时间依赖性且可饱和。H+梯度（[H+]i大于[H+]o）的存在诱导了NEt4+逆其浓度梯度的摄取显著增强（过冲现象），并且这种浓缩摄取受到HgCl2的抑制。这些结果表明，从LLC-PK1细胞分离的顶端膜保留了与在肾刷状缘膜中观察到的类似的NEt4+转运特性。