Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
P&G Innovation Godo Kaisha, Kobe 658-0032, Japan.
Int J Mol Sci. 2018 Jun 4;19(6):1654. doi: 10.3390/ijms19061654.
species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion. However, RCE-mediated IVL upregulation was AHR-dependent but OVOL1-independent. Coordinated upregulation of skin barrier proteins by RCE via AHR may be beneficial in the management of barrier-disrupted inflammatory skin diseases such as atopic dermatitis.
这些物种是具有抗氧化作用的有益植物，已知它们能够抑制表皮角质形成细胞中紫外线和γ 辐射引起的氧化应激。由于某些植物化学物质可以激活芳香烃受体 (AHR) 或 OVO 样 1 (OVOL1)，从而上调表皮屏障蛋白的表达，如丝聚蛋白 (FLG)、兜甲蛋白 (LOR) 和内披蛋白 (IVL)，我们研究了根提取物 (RCE) 对这些蛋白的调节作用。我们证明 RCE 以 AHR-OVOL1 依赖的方式诱导 FLG 和 LOR 的上调。然而，RCE 介导的 IVL 上调是 AHR 依赖性的，但与 OVOL1 无关。RCE 通过 AHR 对皮肤屏障蛋白的协调上调可能有益于管理屏障受损的炎症性皮肤病，如特应性皮炎。
