基于资源化学策略合成茶蓑蛾性信息素。
Synthesis of the Sex Pheromone of the Tea Tussock Moth Based on a Resource Chemistry Strategy.
机构信息
State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling 712100, China.
Shaanxi Key Laboratory for Catalysis, College of Chemical and Environment Science, Shaanxi University of Technology, Hanzhong 723001, China.
出版信息
Molecules. 2018 Jun 4;23(6):1347. doi: 10.3390/molecules23061347.
Synthesis of the sex pheromone of the tea tussock moth in 33% overall yield over 10 steps was achieved. Moreover, the chiral pool concept was applied in the asymmetric synthesis. The synthesis used a chemical available on a large-scale from recycling of wastewater from the steroid industry. The carbon skeleton was constructed using the C4+C5+C8 strategy. Based on this strategy, the original chiral center was totally retained.
以 33%的总收率经 10 步反应实现了茶蓑蛾性信息素的全合成。此外，还在手性池概念的指导下进行了不对称合成。该合成使用了一种可从甾体工业废水的回收中大规模获得的商品化原料。碳骨架采用 C4+C5+C8 策略构建。基于该策略，原始的手性中心完全得以保留。
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