Shibata Takashi, Musha Toshimitu, Kosugi Yukio, Kubo Michiya, Horie Yukio, Tanaka Mieko, Matsuzaki Haruyasu, Kobayashi Yohei, Kuroda Satoshi
Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
Brain Functions Laboratory, Inc., Yokohama, Japan.
Front Hum Neurosci. 2018 May 9;12:170. doi: 10.3389/fnhum.2018.00170. eCollection 2018.
We recently noted a gradual change in the boundary electroencephalography (EEG) oscillation of 7.8 Hz between theta (θ) and alpha (α) bands in response to increased atherosclerosis levels in the elderly. The aim of this study was to investigate the role of boundary EEG oscillations of θ-α bands on cognitive functions in vascular cognitive impairments (VCI) patients. We examined 55 patients with VCI in carotid stenosis, and underwent EEG in a resting state with closed eyes for 5 min. The asymmetry index (AI) along homologous channel pairs (e.g., F7-8) was assessed using neuronal activity topography (NAT). AI referring to 10 frequency components ranging from 4 to 20 Hz and neuropsychological assessments including linguistic competence were analyzed. The main findings was that the language score had a positive association with AI in 7.8 Hz at F7-8 and a negative association with AI in 6.3 Hz at C3-4 and 14.1 Hz at F3-4. EEG asymmetry in a boundary range might have a special role in linguistic competence, suggesting the application of neural oscillation on the cognitive function evaluation and neurorehabilition induced by a frequency-specific transcranial alternating current stimulation.
我们最近注意到，随着老年人动脉粥样硬化水平的升高，θ波和α波之间7.8赫兹的边界脑电图（EEG）振荡出现逐渐变化。本研究的目的是探讨θ-α波段的边界EEG振荡在血管性认知障碍（VCI）患者认知功能中的作用。我们检查了55例颈动脉狭窄的VCI患者，并在闭眼静息状态下进行了5分钟的脑电图检查。使用神经元活动地形图（NAT）评估沿同源通道对（如F7-8）的不对称指数（AI）。分析了涉及4至20赫兹的10个频率成分以及包括语言能力在内神经心理学评估的AI。主要发现是，语言得分与F7-8处7.8赫兹的AI呈正相关，与C3-4处6.3赫兹和F3-4处14.1赫兹的AI呈负相关。边界范围内的脑电图不对称可能在语言能力中具有特殊作用，并表明神经振荡在频率特异性经颅交流电刺激诱导的认知功能评估和神经康复中的应用。
