Xu Tianshu, Kong Zhijun, Zhao Hui
Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Department of General Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.
Front Physiol. 2018 May 15;9:469. doi: 10.3389/fphys.2018.00469. eCollection 2018.
Tumor necrosis factor (TNF)-α, a major part in inflammatory, infectious and tumor processes, and is pivotal at the early stages of gastric cancer. Relationship between its risk and α rs361525 polymorphism has been demonstrated, but remains conflicting and controversial. Therefore, a meta-analysis was conducted to more precisely estimate this relationship. PubMed, Web of Science, EMBASE and CNKI were comprehensively searched to find out relevant articles through October 5, 2017. The strength of the relationship was assessed using pooled odds ratios and 95% confidence intervals. Totally 20 articles were included involving 4,084 cases and 7,010 controls. No significant relationship between α rs361525 polymorphism and increased GC risk was found in the whole populations. Subgroup analyses uncovered α rs361525 polymorphism intensified the risk of GC among Asians under five models, but decreased the risk of GC among Caucasiansin the allelic and dominant models. Subgroup analysis by genotyping methods revealed increased risk for other methods. In conclusion, this meta-analysis suggests α rs361525 polymorphism is related to the risk of GC, especially for Asians.
肿瘤坏死因子（TNF）-α是炎症、感染和肿瘤过程中的主要成分，在胃癌早期起关键作用。其风险与α rs361525多态性之间的关系已得到证实，但仍存在矛盾和争议。因此，进行了一项荟萃分析以更精确地评估这种关系。全面检索了PubMed、科学网、EMBASE和中国知网，以找出截至2017年10月5日的相关文章。使用合并比值比和95%置信区间评估关系强度。共纳入20篇文章，涉及4084例病例和7010例对照。在整个人群中未发现α rs361525多态性与胃癌风险增加之间存在显著关系。亚组分析发现，在五种模型下，α rs361525多态性增加了亚洲人患胃癌的风险，但在等位基因和显性模型中降低了白种人患胃癌的风险。通过基因分型方法进行的亚组分析显示其他方法的风险增加。总之，这项荟萃分析表明α rs361525多态性与胃癌风险相关，尤其是对亚洲人而言。
