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ARMOUR - 一个水稻微小RNA:信使核糖核酸相互作用资源库。

ARMOUR - A Rice miRNA: mRNA Interaction Resource.

作者信息

Sanan-Mishra Neeti, Tripathi Anita, Goswami Kavita, Shukla Rohit N, Vasudevan Madavan, Goswami Hitesh

机构信息

Plant RNAi Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.

Genome Informatics Research Group, Bionivid Technology Private Limited, Bengaluru, India.

出版信息

Front Plant Sci. 2018 May 8;9:602. doi: 10.3389/fpls.2018.00602. eCollection 2018.

Abstract

ARMOUR was developed as A Rice miRNA:mRNA interaction resource. This informative and interactive database includes the experimentally validated expression profiles of miRNAs under different developmental and abiotic stress conditions across seven Indian rice cultivars. This comprehensive database covers 689 known and 1664 predicted novel miRNAs and their expression profiles in more than 38 different tissues or conditions along with their predicted/known target transcripts. The understanding of miRNA:mRNA interactome in regulation of functional cellular machinery is supported by the sequence information of the mature and hairpin structures. ARMOUR provides flexibility to users in querying the database using multiple ways like known gene identifiers, gene ontology identifiers, KEGG identifiers and also allows on the fly fold change analysis and sequence search query with inbuilt BLAST algorithm. ARMOUR database provides a cohesive platform for novel and mature miRNAs and their expression in different experimental conditions and allows searching for their interacting mRNA targets, GO annotation and their involvement in various biological pathways. The ARMOUR database includes a provision for adding more experimental data from users, with an aim to develop it as a platform for sharing and comparing experimental data contributed by research groups working on rice.

摘要

ARMOUR是作为一个水稻miRNA:mRNA相互作用资源而开发的。这个信息丰富且具有交互性的数据库包含了7个印度水稻品种在不同发育和非生物胁迫条件下经实验验证的miRNA表达谱。这个全面的数据库涵盖了689个已知的和1664个预测的新miRNA,以及它们在38种以上不同组织或条件下的表达谱,还有它们预测的/已知的靶转录本。成熟miRNA和发夹结构的序列信息有助于理解miRNA:mRNA相互作用组在调节细胞功能机制中的作用。ARMOUR为用户提供了多种查询数据库的灵活性,比如使用已知基因标识符、基因本体标识符、KEGG标识符等,还允许使用内置的BLAST算法进行即时的倍数变化分析和序列搜索查询。ARMOUR数据库为新的和成熟的miRNA及其在不同实验条件下的表达提供了一个连贯的平台,并允许搜索它们相互作用的mRNA靶标、GO注释以及它们在各种生物途径中的参与情况。ARMOUR数据库提供了一个添加用户更多实验数据的功能,旨在将其发展成为一个用于共享和比较从事水稻研究的研究小组所贡献的实验数据的平台。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7b3/5952065/dcfa7d404193/fpls-09-00602-g001.jpg

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