Lee Hyeon-Jeong, Ock Minsu, Kim Kyu-Pyo, Jo Min-Woo
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Department of Preventive Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Patient Prefer Adherence. 2018 May 23;12:909-918. doi: 10.2147/PPA.S151946. eCollection 2018.
This study aimed to generate utility weights of gastric cancer-related health states from the perspective of the Korean general population.
The Korean adults (age ≥19 years) included in the study were sampled using multistage quota sampling methods stratified by sex, age, and education level. Nine scenarios for hypothetical gastric cancer-related health states were developed and reviewed. After consenting to participate, the subjects were surveyed by trained interviewers using a computer-assisted personal interview method. Participants were asked to perform standard gamble tasks to measure the utility weights of 5 randomly assigned health states (from among nine scenarios). The mean utility weight was calculated for each health state.
Three hundred twenty-six of the 407 adults who completed this study were included in the analysis. The mean utility weights from the standard gamble were 0.857 (no gastric cancer with infection), 0.773 (early gastric cancer [EGC] with endoscopic surgery), 0.779 (EGC with subtotal gastrectomy), 0.767 (EGC with total gastrectomy), 0.602 (advanced gastric cancer with subtotal gastrectomy and adjuvant chemotherapy), 0.643 (advanced gastric cancer with total gastrectomy and adjuvant chemotherapy), 0.522 (advanced gastric cancer with extended gastrectomy and adjuvant chemotherapy), 0.404 (metastatic gastric cancer with palliative chemotherapy), and 0.399 (recurrent gastric cancer with palliative chemotherapy).
This study was the first to comprehensively estimate the utility weights of gastric cancer-related health states in a general population. The utility weights derived from this study could be useful for future economic evaluations related to gastric cancer interventions.
本研究旨在从韩国普通人群的角度生成胃癌相关健康状态的效用权重。
采用按性别、年龄和教育水平分层的多阶段配额抽样方法，对纳入研究的韩国成年人（年龄≥19岁）进行抽样。制定并审查了9种假设的胃癌相关健康状态情景。在同意参与后，由经过培训的访谈员使用计算机辅助个人访谈方法对受试者进行调查。参与者被要求执行标准博弈任务，以测量5个随机分配的健康状态（来自9种情景）的效用权重。计算每种健康状态的平均效用权重。
完成本研究的407名成年人中，有326人纳入分析。标准博弈得出的平均效用权重分别为：0.857（无胃癌伴感染）、0.773（早期胃癌[EGC]行内镜手术）、0.779（EGC行胃次全切除术）、0.767（EGC行全胃切除术）、0.602（进展期胃癌行胃次全切除术及辅助化疗）、0.643（进展期胃癌行全胃切除术及辅助化疗）、0.522（进展期胃癌行扩大胃切除术及辅助化疗）、0.404（转移性胃癌行姑息化疗）和0.399（复发性胃癌行姑息化疗）。
本研究首次全面估计了普通人群中胃癌相关健康状态的效用权重。本研究得出的效用权重可能有助于未来与胃癌干预措施相关的经济评估。
