Yi Dongwon W, Khang Ah Reum, Lee Hye Won, Son Seok Man, Kang Yang Ho
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Diabetes Metab Syndr Obes. 2018 May 23;11:227-240. doi: 10.2147/DMSO.S166875. eCollection 2018.
Muscles play an important role in energy metabolism. Several studies have investigated the association between muscle mass and metabolic syndrome (MetS), reporting conflicting results. However, studies concerning the association between muscle strength and MetS are limited. We aimed to investigate the association between relative handgrip strength (HGS) and MetS in Korean adults.
We analyzed data from 5,014 Korean adults aged ≥20 years (2,472 men and 2,542 women) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2014-2015).
The increasing quartiles of relative HGS (defined as the sum of both hands' HGS divided by body mass index) were inversely associated with the risk of MetS in both men and women (OR, 0.37; 95% CI, 0.30-0.45, vs OR, 0.19; 95% CI, 0.14-0.27, respectively) after multivariable adjustment for age, region of residence, smoking status, heavy alcohol consumption, regular exercise, family income, and education level. On multivariable logistic regression analyses, participants with the highest relative HGS had a significant decrease in relative risk of MetS, compared with those with the lowest relative HGS. The multivariable-adjusted ORs (with 95% CIs) for MetS in quartiles 1, 2, 3, and 4 were 1.00, 0.72 (0.55-0.94), 0.34 (0.26-0.46), and 0.22 (0.15-0.32) in men and 1.00, 0.50 (0.36-0.68), 0.26 (0.17-0.40), and 0.16 (0.09-0.27) in women, respectively.
Relative HGS showed a highly significant inverse association with the risk of MetS in Korean adults, and it can be a novel biomarker for assessing the risk of MetS.
肌肉在能量代谢中发挥着重要作用。多项研究调查了肌肉量与代谢综合征（MetS）之间的关联，结果相互矛盾。然而，关于肌肉力量与MetS之间关联的研究有限。我们旨在调查韩国成年人相对握力（HGS）与MetS之间的关联。
我们分析了5014名年龄≥20岁的韩国成年人（2472名男性和2542名女性）的数据，这些人参加了韩国国家健康与营养检查调查（KNHANES）VI（2014 - 2015年）。
在对年龄、居住地区、吸烟状况、大量饮酒、规律运动、家庭收入和教育水平进行多变量调整后，相对HGS（定义为双手HGS之和除以体重指数）的四分位数增加与男性和女性患MetS的风险呈负相关（男性的比值比[OR]为0.37；95%置信区间[CI]为0.30 - 0.45，女性的OR为0.19；95% CI为0.14 - 0.27）。在多变量逻辑回归分析中，与相对HGS最低的参与者相比，相对HGS最高的参与者患MetS的相对风险显著降低。男性中MetS在第1、2、3和4四分位数的多变量调整OR（及其95% CI）分别为1.00、0.72（0.55 - 0.94）、0.34（0.26 - 0.46）和0.22（0.15 - 0.32），女性分别为1.00、0.50（0.36 - 0.68）、0.26（0.17 - 0.40）和0.16（0.09 - 0.27）。
相对HGS与韩国成年人患MetS的风险呈高度显著的负相关，它可能是评估MetS风险的一种新型生物标志物。
