手术治疗的格雷夫斯病甲亢患者中的偶发性甲状腺癌：一项队列研究的系统评价和荟萃分析
Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies.
作者信息
Jia Qingyi, Li Xiaodan, Liu Ying, Li Ling, Kwong Joey Sw, Ren Kaiyun, Jiang Yong, Sun Xin, Tian Haoming, Li Sheyu
机构信息
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Department of Gastroenterology, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
出版信息
Cancer Manag Res. 2018 May 21;10:1201-1207. doi: 10.2147/CMAR.S164210. eCollection 2018.
BACKGROUND
The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD.
MATERIALS AND METHODS
We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. The last search was updated to January 23, 2018. All statistical tests were performed using Review Manager 5.3 and STATA version 12.0.
RESULTS
Eleven cohort studies involving 10,743 GD and 3,336 non-GD patients were included. The pooled prevalence of ITC was 7.0% (95% confidence interval [CI] 4.5-9.6), and was comparable in surgery-treated GD and non-GD hyperthyroid patients (GD vs non-GD: pooled odds ratio [OR], 1.0; 95% CI: 0.68-1.46; =0.98). In the subgroup analysis, toxic adenoma and toxic nodular goiter showed no difference when comparing with GD (pooled OR, 0.53; 95% CI: 0.21-1.36; =0.18 and pooled OR, 1.01; 95% CI: 0.65-1.57; =0.95, respectively).
CONCLUSION
Our study demonstrated that GD was not associated with increased risk of ITC in surgery-treated hyperthyroid patients.
背景
格雷夫斯病（GD）与甲状腺癌之间的关联仍存在争议。本研究旨在调查接受手术治疗的甲亢患者中有无GD时的意外甲状腺癌（ITC）情况。
材料与方法
我们根据流行病学观察性研究的Meta分析指南，在PubMed和EMBASE中检索了关于接受手术治疗的无预先诊断甲状腺癌的甲亢患者中ITC的队列研究。最后一次检索更新至2018年1月23日。所有统计检验均使用Review Manager 5.3和STATA 12.0版本进行。
结果
纳入了11项队列研究，涉及10,743例GD患者和3,336例非GD患者。ITC的合并患病率为7.0%（95%置信区间[CI] 4.5 - 9.6），在接受手术治疗的GD和非GD甲亢患者中相当（GD与非GD：合并比值比[OR]，1.0；95% CI：0.68 - 1.46；P = 0.98）。在亚组分析中，毒性腺瘤和毒性结节性甲状腺肿与GD相比无差异（合并OR，0.53；95% CI：0.21 - 1.36；P = 0.18和合并OR，1.01；95% CI：0.65 - 1.57；P = 0.95）。
结论
我们的研究表明，在接受手术治疗的甲亢患者中，GD与ITC风险增加无关。
Zotero 插件