Futuro Débora O, Ferreira Patricia G, Nicoletti Caroline D, Borba-Santos Luana P, Silva Fernando C DA, Rozental Sonia, Ferreira Vitor Francisco
Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
PPGCAPS, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói, RJ, Brazil.
An Acad Bras Cienc. 2018;90(1 Suppl 2):1187-1214. doi: 10.1590/0001-3765201820170815.
Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.
萘醌是自然界中最常见的醌类。它们是一类多样的次生代谢产物，天然存在于植物、地衣和各种微生物中。通过发现新的天然产物以及采用创新技术合成新化合物，这个亚组不断扩大。近年来，对醌类以及在这类成员中寻找新生物活性的兴趣有所增强，对醌类潜在抗菌活性的评估就证明了这一点。在具有医学意义的真菌中，念珠菌属酵母因其在人类中高频率的定植和感染而极其重要。本综述的目的是描述萘醌作为抗真菌剂用于治疗念珠菌属物种的发展情况，并指出最有前景的化合物。通过使用某些出版物选择标准，讨论了68篇涉及合成和天然萘醌的报告。评估了大量物质对白色念珠菌以及念珠菌属其他7个物种的活性。本综述中讨论的结果使得能够鉴定出30种抗真菌活性高于目前使用药物的萘醌。
