F.M. Kirby Neurobiology Center , Boston Children's Hospital , Boston , Massachusetts 02115 , United States.
Department of Neurobiology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
Chem Rev. 2018 Nov 14;118(21):10748-10773. doi: 10.1021/acs.chemrev.7b00723. Epub 2018 Jun 6.
Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been developed over the years to treat these diseases or restore vision to already blind patients. In this Review, we describe the development and translational application of light-sensitive chemical photoswitches to restore visual function to the blind retina and compare the translational potential of photoswitches with other vision-restoring therapies. This therapeutic strategy is enabled by an efficient fusion of chemical synthesis, chemical biology, and molecular biology and is broadly applicable to other biological systems. We hope this Review will be of interest to chemists as well as neuroscientists and clinicians.
退行性视网膜疾病，如色素性视网膜炎（RP）和年龄相关性黄斑变性（AMD），影响着全球数以百万计的人，如果不加以治疗，会导致不可逆转的视力丧失。多年来，已经开发出许多治疗这些疾病或恢复已失明患者视力的治疗策略。在这篇综述中，我们描述了光敏化学光开关的发展和转化应用，以恢复盲视网膜的视觉功能，并比较了光开关与其他恢复视力的治疗方法的转化潜力。这种治疗策略是通过化学合成、化学生物学和分子生物学的有效融合实现的，并且广泛适用于其他生物系统。我们希望这篇综述不仅对化学家，而且对神经科学家和临床医生都有兴趣。
