细胞间和细胞内信号传导的核心：闰盘。
At the heart of inter- and intracellular signaling: the intercalated disc.
作者信息
Manring Heather R, Dorn Lisa E, Ex-Willey Aidan, Accornero Federica, Ackermann Maegen A
机构信息
Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
出版信息
Biophys Rev. 2018 Aug;10(4):961-971. doi: 10.1007/s12551-018-0430-7. Epub 2018 Jun 6.
Abstract
Proper cardiac function requires the synchronous mechanical and electrical coupling of individual cardiomyocytes. The intercalated disc (ID) mediates coupling of neighboring myocytes through intercellular signaling. Intercellular communication is highly regulated via intracellular signaling, and signaling pathways originating from the ID control cardiomyocyte remodeling and function. Herein, we present an overview of the inter- and intracellular signaling that occurs at and originates from the intercalated disc in normal physiology and pathophysiology. This review highlights the importance of the intercalated disc as an integrator of signaling events regulating homeostasis and stress responses in the heart and the center of several pathophysiological processes mediating the development of cardiomyopathies.
摘要
正常的心脏功能需要单个心肌细胞的机械和电同步耦合。闰盘（ID）通过细胞间信号传导介导相邻心肌细胞的耦合。细胞间通讯通过细胞内信号传导进行高度调节，源自闰盘的信号通路控制心肌细胞的重塑和功能。在此，我们概述了在正常生理和病理生理状态下发生于闰盘并源自闰盘的细胞间和细胞内信号传导。本综述强调了闰盘作为调节心脏内稳态和应激反应的信号事件整合器以及介导心肌病发展的几个病理生理过程的中心的重要性。
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