Ueda S, Takenaka O, Honjo T
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3712-5. doi: 10.1073/pnas.82.11.3712.
Molecular genetic analyses of the young pseudogenes of the immunoglobulin C epsilon genes were carried out to obtain qualitative evidence for the phylogenetic branching pattern of hominoid primates. We found that Old World monkeys had two C epsilon genes, one of which was processed. Among the hominoids examined only the gorilla and human genomes contained three C epsilon genes: an active, a truncated, and a processed gene. Other hominoids so far examined, including chimpanzee, contained two C epsilon genes: one active and the other processed. These results suggest that the processed C epsilon pseudogene was generated before the divergence between Old World monkeys and hominoids and that the gorilla is more closely related to man than the chimpanzee is, unless the chimpanzee has lost the C epsilon 2 gene after the divergence of this species.
为了获得类人猿灵长类动物系统发育分支模式的定性证据,对免疫球蛋白Cε基因的年轻假基因进行了分子遗传学分析。我们发现,旧世界猴有两个Cε基因,其中一个是加工过的。在所研究的类人猿中,只有大猩猩和人类基因组包含三个Cε基因:一个活性基因、一个截短基因和一个加工过的基因。到目前为止所研究的其他类人猿,包括黑猩猩,都含有两个Cε基因:一个活性基因和另一个加工过的基因。这些结果表明,加工过的Cε假基因是在旧世界猴和类人猿分化之前产生的,并且大猩猩与人类的关系比黑猩猩与人类的关系更密切,除非黑猩猩在该物种分化后失去了Cε2基因。