Durham P J, Johnson R H, Parker R J
Res Vet Sci. 1985 Jul;39(1):16-23.
The disease induced in calves following oral dosing with bovine parvovirus (BPV) was found to be substantially exacerbated when the animals had subclinical coccidiosis. Low levels of passive serum antibody appeared to have little influence on the response to BPV. Imposition of weaning stress on coccidia-infected calves which had apparently recovered from prior infection with BPV, was found to induce severe diarrhoea with recrudescence of BPV excretion in faeces. This was in marked contrast to the relatively mild diarrhoea which was found following weaning of control animals and animals infected with either agent alone. It was concluded that BPV activity and damage in the intestinal tract was probably enhanced as a consequence of the extra mitotic activity induced in the region by coccidial infection and the local effects of weaning. On the basis of these and previous findings in the field, it is suggested that BPV may play a significant role in the aetiology of post-weaning diarrhoea in calves.
研究发现，当小牛患有亚临床球虫病时，口服牛细小病毒（BPV）后引发的疾病会显著加重。低水平的被动血清抗体似乎对BPV反应影响不大。对先前感染BPV后明显康复的球虫感染小牛施加断奶应激，会导致严重腹泻，并使粪便中BPV排泄复发。这与对照动物以及仅感染其中一种病原体的动物断奶后出现的相对轻微腹泻形成鲜明对比。得出的结论是，由于球虫感染在该区域诱导的额外有丝分裂活动以及断奶的局部影响，肠道中的BPV活性和损伤可能会增强。基于这些以及该领域先前的研究结果，表明BPV可能在小牛断奶后腹泻的病因学中起重要作用。
