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母体和生命早期维生素D缺乏会增强卵清蛋白致敏的BALB/c小鼠模型中的过敏反应。

Maternal and early-life vitamin D deficiency enhances allergic reaction in an ovalbumin-sensitized BALB/c mouse model.

作者信息

Wu Jiang, Zhong Yan, Shen Xiuhua, Yang Kefeng, Cai Wei

机构信息

Department of Clinical Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China, 200092.

出版信息

Food Nutr Res. 2018 May 31;62. doi: 10.29219/fnr.v62.1401. eCollection 2018.

DOI:10.29219/fnr.v62.1401
PMID:29881333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5985744/
Abstract

BACKGROUND: Recent studies have shown that vitamin D deficiency may contribute to the high prevalence of food allergy but the underlying mechanisms are far from clear. OBJECTIVE: The present study was designed to investigate the effect of maternal and early-life vitamin D deficiency in the development of food allergy. DESIGN: BALB/c mice were treated with ovalbumin (OVA) to trigger allergic reactions, under vitamin D-deficient (by maternal and early-life feeding of vitamin D deprived chow diet) or vitamin D-sufficient conditions. RESULTS: Increased occurrence and severity of allergic diarrhea as well as decreased rectal temperature were observed after OVA sensitization. For vitamin D deficiency groups, OVA-specific IgE and IL-4 levels were significantly increased, while IFN-γ levels were unchanged. Vitamin D deficiency also attenuated the structure of small intestinal villi and decreased the expression of the tight junction protein between adjacent epithelial cells and the percentages of CD4CD25Foxp3Treg cell in spleen and mesenteric lymph nodes. CONCLUSIONS: Maternal and early-life vitamin D deficiency have notable influence on the susceptibility to food allergy, which may relate with the reduced population of Treg cell and the dysfunction of intestinal epithelial barrier.

摘要

背景：近期研究表明，维生素D缺乏可能导致食物过敏的高患病率，但其潜在机制尚不清楚。 目的：本研究旨在探讨母体及生命早期维生素D缺乏对食物过敏发生发展的影响。 设计：将BALB/c小鼠在维生素D缺乏（通过母体及生命早期喂食缺乏维生素D的饲料）或维生素D充足的条件下，用卵清蛋白（OVA）处理以引发过敏反应。 结果：OVA致敏后，观察到过敏性腹泻的发生率和严重程度增加，直肠温度降低。对于维生素D缺乏组，OVA特异性IgE和IL-4水平显著升高，而IFN-γ水平未改变。维生素D缺乏还使小肠绒毛结构变细，相邻上皮细胞间紧密连接蛋白的表达降低，脾脏和肠系膜淋巴结中CD4CD25Foxp3Treg细胞百分比降低。 结论：母体及生命早期维生素D缺乏对食物过敏易感性有显著影响，这可能与Treg细胞数量减少和肠道上皮屏障功能障碍有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/f113ad7bea1e/FNR-62-1401-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/6c78d561afc7/FNR-62-1401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/ed0bceb8e404/FNR-62-1401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/8844b584417f/FNR-62-1401-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/4693533215f2/FNR-62-1401-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/824174bbe24b/FNR-62-1401-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/67a3b8adedbd/FNR-62-1401-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/f113ad7bea1e/FNR-62-1401-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/6c78d561afc7/FNR-62-1401-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/ed0bceb8e404/FNR-62-1401-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/8844b584417f/FNR-62-1401-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/4693533215f2/FNR-62-1401-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/824174bbe24b/FNR-62-1401-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/67a3b8adedbd/FNR-62-1401-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baa6/5985744/f113ad7bea1e/FNR-62-1401-g007.jpg

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引用本文的文献

[1]
Prenatal vitamin D deficiency exposure leads to long-term changes in immune cell proportions.

Sci Rep. 2024-8-27

[2]
Serum vitamin D status in a cohort of infants with food protein‑induced gastrointestinal disease.

Biomed Rep. 2023-8-30

[3]
Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life.

Front Immunol. 2023

[4]
Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases.

Biomedicines. 2022-8-3

[5]
The Role of Vitamin D in Alzheimer's Disease: A Transcriptional Regulator of Amyloidopathy and Gliopathy.

Biomedicines. 2022-7-28

[6]
Nutrition during Pregnancy and Lactation: Epigenetic Effects on Infants' Immune System in Food Allergy.

Nutrients. 2022-4-23

[7]
Correlation between vitamin D levels and bone metabolism in children with cow's milk allergy.

J Int Med Res. 2022-1

[8]
A narrative review of vitamin D and food allergy in infants and children.

Transl Pediatr. 2021-10

[9]
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[10]
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本文引用的文献

[1]
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J Allergy Clin Immunol. 2014-2

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Cell Tissue Res. 2014-3

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