Saku T, Tsuda N, Anami M, Okabe H
Acta Pathol Jpn. 1985 Jan;35(1):125-36. doi: 10.1111/j.1440-1827.1985.tb02211.x.
Histological localization of myosins of the smooth and skeletal muscles was investigated in comparison with that of myoglobin by immunoperoxidase technique using the antibody against each of them in surgical specimens from spindle cell tumors and tumor-like lesions of the soft tissue. Skeletal muscle myosin was demonstrated in all of the cases of rhabdomyosarcoma, whereas myoglobin was found in 75% of the examined cases. Smooth muscle myosin was widely distributed not only in the tumor cells of smooth muscle origin such as leiomyosarcoma and angioleiomyoma, but also in the tumor cells showing myofibroblastic differentiation such as malignant fibrous histiocytoma and in the epithelial components of synovial sarcoma. The results showed that skeletal muscle myosin can be regarded as an excellent marker in the diagnosis of rhabdomyosarcoma and that smooth muscle myosin is a useful marker of leiomyosarcoma and leiomyomas, and of tumors with myofibroblastic differentiation.
利用针对平滑肌和骨骼肌肌球蛋白以及肌红蛋白的抗体，采用免疫过氧化物酶技术，在软组织梭形细胞瘤和肿瘤样病变的手术标本中，对平滑肌和骨骼肌肌球蛋白的组织学定位与肌红蛋白进行了比较研究。横纹肌肉瘤的所有病例均显示骨骼肌肌球蛋白，而在所检查病例的75%中发现了肌红蛋白。平滑肌肌球蛋白不仅广泛分布于平滑肌来源的肿瘤细胞（如平滑肌肉瘤和血管平滑肌瘤）中，还分布于显示肌纤维母细胞分化的肿瘤细胞（如恶性纤维组织细胞瘤）以及滑膜肉瘤的上皮成分中。结果表明，骨骼肌肌球蛋白可被视为横纹肌肉瘤诊断中的优良标志物，而平滑肌肌球蛋白是平滑肌肉瘤、平滑肌瘤以及具有肌纤维母细胞分化肿瘤的有用标志物。
