BioScience Laboratories, Inc, Bozeman, MT.
Hahn School of Nursing and Health Sciences, University of San Diego, San Diego, CA.
Am J Infect Control. 2018 Nov;46(11):1262-1265. doi: 10.1016/j.ajic.2018.04.232. Epub 2018 Jun 5.
This study evaluated whether a multi-ingredient surfactant colloidal silver technology was noninferior to a 4% chlorhexidine gluconate (CHG) antiseptic on immediate and persistent antimicrobial activity.
The inguinal regions of 81 healthy adults were demarcated into 4 quadrants, and 3 were used for testing each product at baseline, 10 minutes, and 6 hours postapplication. The log of the number of colony forming units was obtained using a cylinder sampling technique. The 95% confidence interval of the test product to the control product with a margin of 0.65 was established as the upper limit of noninferiority.
A total of 81 individuals were enrolled. The colloidal silver product was found to be noninferior to 4% CHG at both 10 minutes and 6 hours postapplication.
The colloidal silver-based product was noninferior to the 4% CHG product at 10 minutes and 6 hours postapplication.
本研究评估了一种多成分表面活性剂胶体银技术在即刻和持久抗菌活性方面是否不劣于 4%葡萄糖酸氯己定（CHG）消毒剂。
81 名健康成年人的腹股沟区域被划分为 4 个象限，每个产品在基线、10 分钟和 6 小时后应用于 3 个象限进行测试。使用圆柱采样技术获得菌落形成单位数量的对数。测试产品与控制产品的 95%置信区间，以 0.65 的差值为非劣效性的上限。
共有 81 名个体入组。胶体银产品在应用后 10 分钟和 6 小时均显示不劣于 4%CHG。
胶体银产品在应用后 10 分钟和 6 小时与 4%CHG 产品相比不劣效。
