Sigvardt K A, Grillner S, Wallén P, Van Dongen P A
Brain Res. 1985 Jun 17;336(2):390-5. doi: 10.1016/0006-8993(85)90676-6.
The motor pattern underlying locomotion in the lamprey can be elicited in the spinal cord in vitro by applying excitatory amino acids that activate NMDA receptors. When this is done oscillatory membrane potentials phase-linked with the locomotory rhythm can be recorded in different types of neurones. In some spinal neurones large amplitude oscillation continues after elimination of synaptic input with application of TTX. This oscillatory pacemaker-like activity is dependent on an activation of NMDA receptors, and is probably important in the generation of locomotion.
通过应用激活NMDA受体的兴奋性氨基酸，七鳃鳗运动背后的运动模式可以在体外脊髓中诱发出来。当这样做时，可以在不同类型的神经元中记录到与运动节律相位相关的振荡膜电位。在一些脊髓神经元中，应用TTX消除突触输入后，仍会持续出现大幅度振荡。这种类似振荡起搏器的活动依赖于NMDA受体的激活，并且可能在运动的产生中起重要作用。
