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本文引用的文献

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Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation.差异表达的长链非编码RNA和环状RNA的鉴定与综合分析揭示了牙周膜干细胞成骨分化过程中的潜在竞争性内源RNA网络。
BMC Genet. 2017 Dec 2;18(1):100. doi: 10.1186/s12863-017-0569-4.
2
Lnc-NTF3-5 promotes osteogenic differentiation of maxillary sinus membrane stem cells via sponging miR-93-3p.Lnc-NTF3-5 通过海绵吸附 miR-93-3p 促进上颌窦膜干细胞的成骨分化。
Clin Implant Dent Relat Res. 2018 Apr;20(2):110-121. doi: 10.1111/cid.12553. Epub 2017 Nov 6.
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Systematic analysis of lncRNAs, miRNAs and mRNAs for the identification of biomarkers for osteoporosis in the mandible of ovariectomized mice.对去卵巢小鼠下颌骨中lncRNA、miRNA和mRNA进行系统分析以鉴定骨质疏松症生物标志物。
Int J Mol Med. 2017 Sep;40(3):689-702. doi: 10.3892/ijmm.2017.3062. Epub 2017 Jul 10.
4
LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p.长链非编码 RNA MEG3 通过靶向 miR-133a-3p 抑制绝经后骨质疏松症骨髓间充质干细胞的成骨分化。
Biomed Pharmacother. 2017 May;89:1178-1186. doi: 10.1016/j.biopha.2017.02.090. Epub 2017 Mar 14.
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Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice.补骨脂素通过调节骨保护素基因敲除小鼠的PI3K/AKT、JNK/MAPK和NF-κB信号通路，对糖尿病相关骨质疏松症发挥抑制作用。
Int J Mol Med. 2016 Dec;38(6):1661-1672. doi: 10.3892/ijmm.2016.2794. Epub 2016 Nov 2.
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Long non-coding RNA MIAT knockdown promotes osteogenic differentiation of human adipose-derived stem cells.长链非编码RNA MIAT敲低促进人脂肪来源干细胞的成骨分化。
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Eur Rev Med Pharmacol Sci. 2016 Sep;20(17):3561-5.
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Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches.非编码 RNA 在发育和疾病中的作用：背景、机制与治疗方法。
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Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.膀胱癌中lncRNAs和circRNAs差异表达谱及其相关共表达和ceRNA网络的综合分析
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绝经后骨质疏松症患者lncRNA、mRNA、circRNA和miRNA的系统分析

Systematic analysis of lncRNAs, mRNAs, circRNAs and miRNAs in patients with postmenopausal osteoporosis.

作者信息

Jin Di, Wu Xiaowei, Yu Hongwen, Jiang Lihong, Zhou Ping, Yao Xiaoyi, Meng Jia, Wang Liping, Zhang Meijie, Zhang Yina

机构信息

Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University NO. 246 Xuefu Road, Nangang District, Harbin 150086, China.

Department of Orthopaedics, Fifth Hospital of Harbin NO. 27 Jiankang Road, Xiangfang District, Harbin 150040, China.

出版信息

Am J Transl Res. 2018 May 15;10(5):1498-1510. eCollection 2018.

PMID:29887963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5992556/
Abstract

Osteoporosis (OP) is a disease characterized by bone loss, imbalance of bone metabolism and destruction of trabecular microstructure, and associated with menopause. Studies have shown that immune related lymphocytes are involved in bone metabolism. However, the molecular mechanisms hidden in the interaction of lymphocytes with OP need to be further studied. In the present study, we investigated the expression profiles and differences of lncRNAs, mRNAs, circRNAs and miRNAs in peripheral blood lymphocytes of patients with postmenopausal OP using Illumina-based complementary DNA (cDNA) deep sequencing (RNA-seq). 70 lncRNAs, 475 mRNAs, 260 circRNAs and 13 miRNAs were differentially expressed in patients with postmenopausal osteoporosis (OP group) compared with healthy controls (NC group). The functions of differentially expressed lncRNAs, circRNA, miRNA and potential targeting genes were predicted by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Complex lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA regulatory networks were constructed based on differentially expressed RNAs. Taken together, our study indicated that lncRNAs, mRNA, circRNAs and miRNA could associate with the occurrence of postmenopausal OP and may be as possible biomarkers and target genes in lymphocytes for OP.

摘要

骨质疏松症（OP）是一种以骨质流失、骨代谢失衡和小梁微结构破坏为特征，并与绝经相关的疾病。研究表明，免疫相关淋巴细胞参与骨代谢。然而，淋巴细胞与OP相互作用中隐藏的分子机制有待进一步研究。在本研究中，我们使用基于Illumina的互补DNA（cDNA）深度测序（RNA测序）研究绝经后OP患者外周血淋巴细胞中lncRNA、mRNA、circRNA和miRNA的表达谱及差异。与健康对照（NC组）相比，绝经后骨质疏松症患者（OP组）中有70种lncRNA、475种mRNA、260种circRNA和13种miRNA差异表达。通过基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析预测差异表达的lncRNA、circRNA、miRNA及其潜在靶向基因的功能。基于差异表达的RNA构建了复杂的lncRNA-miRNA-mRNA和circRNA-miRNA-mRNA调控网络。综上所述，我们的研究表明lncRNA、mRNA、circRNA和miRNA可能与绝经后OP的发生有关，并且可能作为OP淋巴细胞中的潜在生物标志物和靶基因。