脂质代谢与致癌作用、癌症发展。
Lipid metabolism and carcinogenesis, cancer development.
作者信息
Long Jia, Zhang Chan-Juan, Zhu Neng, Du Ke, Yin Yu-Fang, Tan Xi, Liao Duan-Fang, Qin Li
机构信息
School of Pharmacy, Hunan University of Chinese Medicine Changsha, Hunan, China.
The First Affiliated Hospital, Hunan University of Chinese Medicine Changsha, Hunan, China.
出版信息
Am J Cancer Res. 2018 May 1;8(5):778-791. eCollection 2018.
Abstract
The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further elucidation of molecular mechanism between lipid metabolism and cancer is essential in developing novel diagnostic biomarkers and therapeutic targets of human cancers.
摘要
脂质代谢紊乱在病理上与高脂血症、脂质贮积病、肥胖及其他相关疾病有关。有趣的是，最近的研究表明，脂质代谢紊乱在癌症的发生和发展中也起着重要作用，因为它们会导致各种基因、蛋白质的异常表达以及细胞因子和信号通路的失调。更重要的是，与其他毒性高的抗癌药物相比，降脂药物和抗脂质过氧化治疗在临床上已显示出其优势。因此，进一步阐明脂质代谢与癌症之间的分子机制对于开发人类癌症的新型诊断生物标志物和治疗靶点至关重要。
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