National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Department of Pharmaceutics, Opposite Air Force Station, Palaj, Gandhinagar 382355, Gujarat, India.
Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Drug Discov Today. 2017 Nov;22(11):1637-1653. doi: 10.1016/j.drudis.2017.08.003. Epub 2017 Aug 24.
Tumor cells are known for their propensity to proliferate uncontrollably and generate multitudes of metastatic masses at the advanced stages of cancer. During this progression, tumor cells switch their energy source from mitochondrial oxidative phosphorylation to a glucose-dependent glycolytic pathway, despite the availability of oxygen. Consequently, tumor cells increase their metabolic rates as well as glucose uptake to maintain their proliferation. This atypical metabolic phenomenon is known as the Warburg effect, which has been recognized as a hallmark of cancer and serves as a promising target for diagnosis and therapy of cancer. In this review, we summarize the current advances toward the development of glucose-derived therapeutic and diagnostic agents (theranostics) of cancer.
肿瘤细胞以其不受控制的增殖倾向和在癌症晚期产生大量转移灶而闻名。在这个过程中，肿瘤细胞尽管有氧气的存在，但其能量来源从线粒体氧化磷酸化切换到葡萄糖依赖性糖酵解途径。因此，肿瘤细胞增加代谢率和葡萄糖摄取以维持其增殖。这种非典型的代谢现象被称为瓦博格效应，它已被认为是癌症的一个标志，并作为癌症诊断和治疗的一个有前途的靶点。在这篇综述中，我们总结了开发葡萄糖衍生的治疗和诊断癌症的试剂（治疗诊断学）的最新进展。
