Anderson W P, Ramsey D E
Clin Exp Hypertens A. 1985;7(4):525-37. doi: 10.3109/10641968509077210.
The hypothesis that interactions between adrenaline and adrenal cortical hormones may increase arterial blood pressure has been examined in trained dogs with chronically indwelling aortic and venous catheters. The dogs received continuous infusions for 4 days of ACTH (400 micrograms/day), or adrenaline (8 mg/day) or both ACTH and adrenaline, or saline vehicle. Compared to pre-infusion control values, ACTH raised mean arterial pressure by 14.9 +/- 2.2 mmHg by the 4th day of infusion, adrenaline infused alone had no effect (-0.2 +/- 3.9 mmHg), and ACTH and adrenaline infused together raised pressure 13.1 +/- 3.2 mmHg (not significantly different to ACTH alone). ACTH increased water consumption, Na+ and K+ excretion and creatinine clearance by the 4th day of infusion and these effects were not significantly altered when adrenaline was also infused. Thus adrenaline did not potentiate the hypertension produced by ACTH administration.
肾上腺素与肾上腺皮质激素之间的相互作用可能会升高动脉血压这一假说，已在通过长期留置主动脉和静脉导管进行训练的犬类身上进行了检验。这些犬连续4天接受促肾上腺皮质激素（400微克/天）、肾上腺素（8毫克/天）、促肾上腺皮质激素和肾上腺素联合输注或生理盐水载体的输注。与输注前的对照值相比，输注促肾上腺皮质激素至第4天时，平均动脉压升高了14.9±2.2毫米汞柱，单独输注肾上腺素无作用（-0.2±3.9毫米汞柱），促肾上腺皮质激素和肾上腺素联合输注使血压升高了13.1±3.2毫米汞柱（与单独输注促肾上腺皮质激素无显著差异）。输注促肾上腺皮质激素至第4天时，其增加了水的消耗量、钠和钾的排泄以及肌酐清除率，当同时输注肾上腺素时，这些作用没有显著改变。因此，肾上腺素不会增强促肾上腺皮质激素给药所产生的高血压。
