Lifson J D, Finch S L, Sasaki D T, Engleman E G
Clin Immunol Immunopathol. 1985 Aug;36(2):151-60. doi: 10.1016/0090-1229(85)90116-3.
Inversion of the normal ratio of helper/inducer (Th) to suppressor/cytotoxic (Ts) T lymphocytes is a characteristic finding in symptomatic and presymptomatic patients with acquired immunodeficiency syndrome (AIDS). As an interim measure to prevent transmission of AIDS via blood transfusion, the Stanford Blood Center performed T-lymphocyte subset analysis as a screening procedure. In this report we present results from 8715 consecutive volunteer blood donors, aged 17-77. The mean Th:Ts ratio was 2.00 +/- 0.70 with a significant trend for increasing Th:Ts with increasing age. In all age groups, donors with antibody to cytomegalovirus (CMV) had lower Th:Ts ratios than CMV-seronegative donors. 1.9% of the donors had Th:Ts values less than or equal to 0.85 and blood from these donors was not used for clinical purposes. Compared to the overall donor population, individuals with Th:Ts less than or equal to 0.85 tended to be male, (79 vs 53%) and CMV sero-positive (71 vs 36%); a majority (83%) had a low absolute number of Th cells as well as a low Th:Ts value. Follow-up of donors with low Th:Ts values revealed that some belonged to AIDS high-risk populations, despite denials at the time of donation. One such donor was diagnosed with disseminated Kaposi's sarcoma 8 months after a markedly abnormal T-lymphocyte subset profile was noted during screening. These results suggest that T-lymphocyte subset analysis is capable of identifying at least some blood donors at risk for transmitting AIDS and also point to variable affecting T-cell subsets in apparently healthy blood donors.
辅助/诱导型（Th）与抑制/细胞毒性型（Ts）T淋巴细胞的正常比例倒置是获得性免疫缺陷综合征（AIDS）有症状和无症状患者的一个特征性表现。作为预防AIDS通过输血传播的一项临时措施，斯坦福血液中心进行了T淋巴细胞亚群分析作为一种筛查程序。在本报告中，我们呈现了8715名年龄在17至77岁之间连续的志愿献血者的结果。Th:Ts平均比例为2.00±0.70，且随着年龄增长Th:Ts有显著上升趋势。在所有年龄组中，巨细胞病毒（CMV）抗体阳性的献血者的Th:Ts比例低于CMV血清阴性的献血者。1.9%的献血者Th:Ts值小于或等于0.85，这些献血者的血液未用于临床目的。与总体献血人群相比，Th:Ts小于或等于0.85的个体倾向于是男性（79%对53%）且CMV血清阳性（71%对36%）；大多数（83%）的Th细胞绝对数量低且Th:Ts值也低。对Th:Ts值低的献血者的随访显示，尽管他们在献血时否认，但其中一些属于AIDS高危人群。一名这样的献血者在筛查时发现T淋巴细胞亚群谱明显异常8个月后被诊断为播散性卡波西肉瘤。这些结果表明，T淋巴细胞亚群分析能够识别至少一些有传播AIDS风险的献血者，也指出了影响明显健康献血者T细胞亚群的变量。
