Byers V S, Levin A S, Ozonoff D M, Baldwin R W
Cancer Research Campaign Laboratories, University of Nottingham, U.K.
Cancer Immunol Immunother. 1988;27(1):77-81. doi: 10.1007/BF00205762.
An unusually high incidence of leukaemia and recurrent infections was noted in children exposed in utero to domestic water supply contaminated with industrial solvents including trichloroethylene, perchloroethylene and 1,2-transdichloroethylene. Medical and laboratory investigations were carried out on 28 family members of the patients with leukaemia with particular emphasis on the immunological system to determine if they displayed symptoms associated with acute or chronic exposure to these chlorinated hydrocarbons. The principal organ systems affected were neurological, immunological and cardiological. Damage to these systems was found in all subjects by history, physical and laboratory parameters. Damage to the immunological system was manifest by altered ratios of T lymphocyte subpopulations, increased incidence of auto-antibodies, increased infections and recurrent rashes.
在子宫内接触到被包括三氯乙烯、全氯乙烯和反式-1,2-二氯乙烯在内的工业溶剂污染的家庭供水的儿童中，发现白血病和反复感染的发病率异常高。对28名白血病患者的家庭成员进行了医学和实验室调查，特别关注免疫系统，以确定他们是否表现出与急性或慢性接触这些氯代烃相关的症状。受影响的主要器官系统是神经、免疫和心脏系统。通过病史、体格检查和实验室参数发现，所有受试者的这些系统均有损伤。免疫系统损伤表现为T淋巴细胞亚群比例改变、自身抗体发生率增加、感染增多和反复出现皮疹。
